摘要
目的探讨化疗辅助放疗治疗宫颈癌患者的临床疗效和不良反应。方法选取2013年10月至2014年10月间在河北大学附属医院确诊的60例宫颈癌局部晚期患者为研究对象,采用随机数字表法随机分为观察组和对照组,每组30例。观察组患者采用化疗辅助放疗联合甘氨双唑钠治疗,对照组患者采用放疗联合甘氨双唑钠治疗,评价两组患者的近期疗效、不良反应、6个月和1年的生存率。结果观察组患者总有效率为86.7%,对照组为63.3%,组间差异有统计学意义(P<0.05)。两组患者并发症主要为放射性直肠炎和放射性膀胱炎,观察组患者的并发症发生率低于对照组,差异均有统计学意义(均P<0.05)。两组患者的不良反应主要为脱发、贫血、发热、血小板下降、白细胞下降和消化道反应等,差异均无统计学意义(均P>0.05)。观察组患者6个月和1年的生存率分别为83.3%和76.7%,对照组分别为76.7%和63.3%,组间差异均无统计学意义(P>0.05)。结论放疗联合甘氨双唑钠治疗宫颈癌患者疗效较差,不良反应多,而化疗辅助放疗可提高患者的近期疗效,减少并发症发生率。
Objective To explore the efficacy and adverse reactions of chemotherapy adjuvant to radiotherapy in patients with cervical cancer. Methods A total of 60 patients diagnosed with locally advanced cervical cancer were selected and randomly divided into control group and observation group in Affiliated Hospital of Hebei University from October 2013 to October 2014. Patients in the observation group were treated with chemotherapy combined with radiotherapy and sodium glycididazole,while patients in the control group were treated with radiotherapy combined with sodium glycididazole. Short-term efficacy,adverse reactions and survival rate at 6 month and 1 year after treatment were evaluated between the two groups. Results The total effective rate in control group was 63. 3%,which was lower than 86. 7% in the observation group（ P〈 0. 05）. The main complications in both groups were radiation induced proctopathy and cystitis,and the incidence in the control group was higher than the observation group（ P〈 0. 05）. The primary adverse reactions were hair loss,anemia,fever,platelet loss,decreased white blood cells and gastrointestinal reaction for the two groups（ P〈 0. 05）. The 6-month and 1-year survival rates were 76. 7% and 63. 3% respectively for the control group and 83. 3% and 76. 7% respectively for the observation group（ P〈 0. 05）.Conclusion Radiotherapy combined with sodium glycididazol has poor efficacy with more side effects for cervical cancer. On the contrary,chemotherapy adjuvant to radiotherapy is able to significantly improve the short-term efficacy and decrease the incidence of complications.
出处
《中国肿瘤临床与康复》
2016年第10期1204-1206,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
宫颈肿瘤
放射疗法
药物疗法
治疗效果
Uterine cervical neoplasms
Radiotherapy
Drug therapy
Treatment outcome
