摘要
为了观察和探讨附子理中汤合四神丸加味治疗脾肾阳虚型溃疡性结肠炎（UC）的临床疗效和机制，将50例溃疡性结肠炎脾肾阳虚型患者随机分为治疗组（健脾温肾方组）和对照组（柳氮磺吡啶组），每组各25例。观察治疗前后2组的临床症状、体征、肠镜、炎症指标（血沉、C反应蛋白）及复发率、不良反应等情况。结果显示，治疗组总有效率为96．0％（24／25），对照组总有效率为84．0％（21／25），治疗组疗效明显优于对照组，差异具有统计学意义（P〈0．05）。治疗组在中医证候及炎症指标改善方面亦优于对照组，而且治疗组不良反应发生少。结果表明，附子理中汤合四神丸加味足治疗脾肾阳虚型UC安全有效的中药组方，其机制可能与调节机体免疫功能、调节胃肠运动等作用有关，为临床治疗UC提供了一种安全有效的方法，为借床应用提供客观的理论依据。
This study was to observe and explore the clinical efficacy ~ mechanism of modified Fuzilizhong decoction plus Sishen pill to treat ulcerative colitis（UC） predominated by yang deficiency of spleen and kidney;divided 50 cases with this disease into treatment group （invigorate spleen and warm kidney formula group） and control group （Sulfasalazine group）, 25 cases for each; observed such conditions as clinical symptoms, physical sign, colonoscopy, inflammatory indicator （erythrocyte sedimentation rate, C-reactive protein） ,occurrence rate and adverse reaction before and after treatment of the two groups. Results show that in total effective rate,the former （96.0% ,24/25） was obviously superior to the latter （84.0% ,21/25） ; there was statistical significance in difference （ p 〈0.05）. In symptoms of TCM and inflammatory indicators,the former was also superior to the latter and its adverse reaction was less. In conclusion, modified Fuzilizhong decoction plus Sishen pill was a safe and effective traditional Chinese medicine formula treating UC predominated by yang deficiency of spleen and kidney; its mechanism was probably related to regula- ting body immunological function and gastrointestinal motion,which offers a safe and effective therapeutic method for clinically treating UC and provides an objective theoretical foundation for clinical application.
出处
《中国肛肠病杂志》
2016年第9期38-41,共4页
Chinese Journal of Coloproctology
关键词
溃疡性结肠炎
脾肾阳虚型
附子理中丸
四神丸
临床疗效
Ulcerative colitis
Type of yang deficiency of spleen and kidney
Fuzilizhong pill
Sishen pill
Clinical efficacy
