摘要
目的探讨氨氯地平联合阿托伐他汀对高血压合并高血脂患者内皮功能的影响及治疗效果。方法回顾性分析我院92例高血压合并高血脂患者病例资料,根据用药不同分为对照组与治疗组,对照组给予阿托伐他汀治疗,治疗组采用氨氯地平联合阿托伐他汀治疗,连续治疗4周为一疗程,3个疗程后观察两组患者的治疗效果、内皮功能及炎症因子指标的变化。结果治疗后,治疗组的收缩压和舒张压显著低于对照组,治疗组的血脂指标改善情况优于对照组,两组比较具有显著差异(P<0.05);治疗组的一氧化氮(NO)、内皮素-1(ET-1)、C-反应蛋白(CRP)、同型半胱氨酸(Hcy)改善均优于对照组(P<0.05)。结论氨氯地平联合阿托伐他汀治疗高血压合并高血脂可以明显降低患者的血压,改善血脂,及改善患者的内皮功能并抗感染,效果确切。
Objective To study the effects of amlodipine combined with atorvastatin on endothelial function in patients with hypertension and hyperlipidemia and its therapeutic effect. Methods Data of 92 patients with hypertension complicated with hyperlipidemia were retrospectively analyzed. The patients were divided into the control group and the treatment group according to different medications. The control group was treated with atorvastatin, and the treatment group was treated with amlodipine combined with atorvastatin. One course of treatment was 4 consecutive weeks. The therapeutic effect, endothelial function and inflammatory factors were observed after 3 courses of treatment. The treatment group was treated with amlodipine combined with atorvastatin for 4 weeks. The therapeutic effect, endothelial function and inflammatory factors were observed after 3 courses of treatment. Results After treatment, the systolic blood pressure and diastolic blood pressure in the treatment group were significantly lower than those in the control group. The improvement of blood lipid indices in the treatment group was better than that in the control group. There was significant difference between the two groups （P〈0.05）; the levels of nitric oxide（NO）, endothelin-1（ET-1）, C-reactive protein（CRP） and homocysteine（Hcy） in the treatment group were significantly improved compared with those in the control group, and the differences were significant between the two groups （P〈0.05）. Conclusion Amlodipine combined with atorvastatin in the treatment of hypertension complicated with hyperlipidemia can significantly reduce patients＇ blood pressure, improve blood lipids, and improve endothelial function and achieve anti-infection, which has exact curative effects.
出处
《中国现代医生》
2016年第27期112-114,共3页
China Modern Doctor
关键词
氨氯地平
阿托伐他汀
高血压
高血脂
内皮功能
炎症因子
Amlodipine
Atorvastatin
Hypertension
Hyperlipidemia
Endothelial function
Inflammatory factors
