摘要
目的分析柳州市柳铁中心医院（以下简称“我院”）活血类中药注射剂的使用情况及其对策。方法收集我院2011年1月～2015年12月药物不良反应（ADR）共403例，采用集中监测的方法对我院ADR的发生情况进行监测，统计我院活血类中药注射剂致不良反应患者的年龄分布、现有活血类中药注射剂品种的不良反应发生率、活血类注射剂所致ADR主要累及的系统或器官及临床表现等。结果403例ADR中，活血类中药注射剂致不良反应的患者共45例，不良反应发生率为11．2％，其中男19例，女26例，年龄23～86岁，平均56．4岁，其中41～60岁者（17例）居多，占总数的37．78％。我院常用的活血类中药注射剂品种前5名包括输血宁、血塞通、血栓通、灯盏细辛、灯盏花素，发生率分别为0．31％、0．25％、0．14％、0．13％、0．03％。45例活血类中药注射剂ADR报告显示，其主要累及的系统有皮肤及附件损害（30．00％），主要表现为皮疹、瘙痒、斑丘疹；其次为循环系统损害（25．00％），主要表现为胸闷、胸痛、血压升高、心悸、潮红、水肿。结论我院活血类中药注射剂不良反应的集中监测获得相关不良反应发生率不高，不良反应以皮肤及附件损害为主，且累及机体多个系统，其中以黄酮类为主要成分的舒血宁注射液使用最多。降低不良反应发生率应从综合干预的角度出发，加强应用知识的宣传，监管中药注射剂的质量．减少联合用药．并规范药品适用证。
Objective To analyze the using status and its countermeasure of blood-activating TCM injections in Liutie Central Hospital of Liuzhou City （＂our hospital＂ for short）. Methods Total of 403 cases of adverse drug reactions （ADR） in our hospital from January 2011 to December 2015 were collected. By the method of centralized monitoring, the occurrence of ADR in our hospital was monitored, the age distribution of patients with adverse reactions result from blood-activating TCM injections, the incidence of existing varieties of blood-activating TCM injections, and the main systems or organs and clinical features of ADR result from blood-activating TCM injections were counted. Results Among 403 cases with ADR, there were 45 cases with ADR result from blood-activating TCM injections, the incidence of adverse reactions was 11.2%, among whom, male had 19 cases, female had 26 cases, 23-86 years old, with an average age of 56.4 years, 17 cases of 41-60 years old patients were in the majority, accounted for 37.78% of the total number. The first 5 blood-activating TCM injections were Shuxuening, Xuesaitong, Xueshuantong, Dengzhan Xixin, breviscapine, the incidence of which was 0.31%, 0.25%, 0.14%, 0.13%, 0.03% respectively. The reports of 45 cases of ADR result from blood-activating TCM injections showed that, the mainly involved systems were skin and accessories injury （30.00%）, showing rash, pruritus, maculopapule; the next involved systems were circulatory system injury （25.00%）, showing chest distress, chest pain, elevation of blood pressure, palpitation, flushing, edema. Conclusion The incidence of related adverse reactions obtained from the centralized monitoring of adverse reactions result from blood-activating TCM injections in our hospital is not very high, the main adverse reactions are skin and accessories injury, and multiple systems are involved, among which, the usage of Shuxuening Injection with flavonoid as the main ingredients is more frequency. Decreasing the incidence of adverse reactions should start from the view of comprehensive intervention, such as strengthening the publicity of application knowledge, taking charge of the quality of TCM injections, reducing drug combination, and correcting the indication of drugs.
出处
《中国医药导报》
CAS
2016年第30期79-82,共4页
China Medical Herald
关键词
活血类中药注射剂
药物不良反应
监测
对策
Blood-activating TCM injections
Adverse drug reactions
Monitoring
Countermeasures
