摘要
目的比较丹参注射液与丹红注射液辅助治疗急性脑梗死的临床疗效。方法选取2015年2月—2016年2月宝鸡市人民医院收治的急性脑梗死患者106例,随机分为A组与B组,每组53例。两组患者均予以常规治疗,在此基础上,A组患者予以丹红注射液治疗,B组患者予以丹参注射液治疗;两组患者均连续治疗2周。比较两组患者临床疗效,治疗前、治疗第8、14天美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分、血清同型半胱氨酸(Hcy)水平,不良反应发生情况。结果 A组患者临床疗效优于B组(P<0.05)。治疗前、治疗第8天两组患者NIHSS评分、BI评分比较,差异无统计学意义(P>0.05);治疗第14天A组患者NIHSS评分低于B组,BI评分高于B组(P<0.05)。治疗前两组患者血清Hcy水平比较,差异无统计学意义(P>0.05);治疗第8、14天A组患者血清Hcy水平低于B组(P<0.05)。两组患者均未发生严重不良反应。结论丹红注射液辅助治疗急性脑梗死的临床疗效优于丹参注射液,其能更有效地改善患者神经功能,降低患者血清Hcy水平。
Objective To compare the clinical effect in the adjuvant therapy for acute cerebral infarction between danshen injection and danhong injection. Methods A total of 106 patients with acute cerebral infarction were selected in the People＇ s Hospital of Baoji from February 2015 to February 2016, and they were randomly divided into control group and observation group,each of 53 cases. Based on conventional treatment,patients of A group received extra danhong injection,while patients of B group received extra danshen injection; both groups continuously treated for 2 weeks. Clinical effect,NIHSS score,Barthel index and serum homocysteine level before treatment,after 8 days and 14 days of treatment,and incidence of adverse reactions were compared between the two groups. Results The clinical effect of A group was statistically significantly better than that of B group（ P〈0. 05）. No statistically significant differences of NIHSS score or Barthel index was found between the two groups before treatment or after 8 days of treatment（ P〉0. 05）; after 14 days of treatment,NIHSS score of A group was statistically significantly lower than that of B group,while Barthel index of A group was statistically significantly higher than that of B group（ P〈0. 05）. No statistically significant differences of serum homocysteine level was found between the two groups before treatment（ P〉0. 05）,while serum homocysteine level of A group was statistically significantly lower than that of B group after 8 and 14 days of treatment,respectively（ P〈0. 05）. No one of the two group occurred any serious adverse reactions during the treatment. Conclusion Danhong injection has better clinical effect than danshen injection in the adjuvant therapy for acute cerebral infarction,can more effectively improve the neurological function and reduce the serum homocysteine level.
出处
《实用心脑肺血管病杂志》
2016年第10期66-68,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
丹参注射液
丹红注射液
疗效比较研究
Brain infarction
Danshen injection
Danhong injection
Comparative effectiveness research
