摘要
目的：探讨依达拉奉联合神经节苷脂治疗急性脑梗死患者的临床疗效，评估对神经功能的改善作用及预后，为临床治疗急性脑梗死提供依据。方法选择126例急性脑梗死患者，按照入院编号根据单双数随机分为对照组和研究组，两组各63例，对照组患者在常规治疗基础上应用依达拉奉治疗，研究组患者给予依达拉奉联合神经节苷脂治疗。评估两组患者治疗效果，并应用美国国立卫生研究院卒中量表（NIHSS）、Fugl-Meyer 运动功能评分法、巴氏指数（BI）评估治疗前后神经功能、肢体功能及日常生活改善状况。结果研究组总有效率为82．54％，高于对照组的71．43％，差异有统计学意义（χ2＝9．63，P ＜0．05），研究组治疗后NIHSS 评分为（24．60±5．81）分，低于对照组治疗后（27．74±5．93）分，差异有统计学意义（t ＝9．97，P ＜0．05）；研究组治疗后 FM和 BI 评分分别为（78．62±8．46）分和（72．89±8．03）分，均高于对照组的（73．58±8．09）分和（68．30±7．45）分，差异均有统计学意义（t ＝10．16、11．42，均 P ＜0．05）。结论依达拉奉联合神经节苷脂治疗急性脑梗死患者具有较好的临床疗效，能够显著提高患者神经功能和肢体运动功能，对患者的预后改善明显。
Objective To evaluate the clinical efficacy of ganglioside combined with edaravone in the treatment patients with acute cerebral infarction,to assess the improvement of neurological function and prognosis.To provide the evidence for the clinical treatment of acute cerebral infarction.Methods 126 patients with acute cerebral infarction were selected.According to the digital table,they were randomly divided into the control and the study group,with 65 cases in each group.The control group was given edaravone based on the conventional treatment,the study group was treated with ganglioside and edaravone.The treatment effect was assessed,and the National Institutes of Health Stroke Scale（NIHSS）,Fugl -Meyer motor function score,Barthel Index（BI）to assess the improvement of the situation neurological,physical function and daily life were applied.Results The total effective rate of the study group was 82.54%,which was higher than 71.43% of the control group,the difference was statistically significant（χ2 =9.63, P 〈0.05）.The NIHSS score of the study group after treatment was （24.60 ±5.81 ）points,which was lower than （27.74 ±5.93）points of the control group,the difference was statistically significant（t =9.97,P 〈0.05）.The FM and BI scores of the study group after treatment were （78.62 ±8.46）points and （72.89 ±8.03）points,which were higher than （73.58 ±8.09）points and （68.30 ±7.45）points of the control group,the differences were statistically significant（t =10.16,11.42,all P 〈0.05）.Conclusion It has better clinical effect on ganglioside and edaravone for the patients with acute cerebral infarction,which can significantly improve neurological function and limb motor function,and significantly improved prognosis of patients.
作者
王守章
Wang Shouzhang(Department of Neurology, Zhejiang Xin ＇ an International Hospital, Jiangxing , Zhejiang 314031, China)
出处
《中国基层医药》
CAS
2016年第21期3314-3317,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑梗死
依达拉奉
神经节苷脂
治疗结果
预后
Brain infarction
Edaravone
Gangliosides
Treatment outcome
Prognosis
