摘要
目的探索检测降钙素原(PCT)的水平对肺癌围手术期患者合理应用抗菌药物的临床意义。方法选取临沂市中医医院2015年7月至2016年1月经诊断为肺癌需要择期手术治疗者60例,随机分为对照组和治疗组各30例,对照组给予对症治疗和标准抗生素治疗,依据临床检查血常规、体温等决定何时停用抗生素;治疗组则给予在PCT监测下的抗生素治疗,当PCT<0.5ng/ml时停用抗生素。比较两组患者抗生素应用天数、感染并发症发生率及治愈时间。结果治疗组抗生素使用时间、治愈时间均短于对照组,但抗生素使用时间差异有统计学意义(P<0.05),治愈时间和两组感染并发症发生率差异无统计学意义(P>0.05)。结论监测肺癌围手术期患者PCT并根据其水平来指导肺癌围手术期抗生素的应用,可明显缩短抗生素的使用时间,同时并不增加感染并发症的发生率,也不会延长治愈时间,值得临床上推广应用。
Objective To explore the value of detecting procalcitonin （PCT） level in patients with lung cancer in the perioperative rational use of antibacterial drugs. Methods 60 cases of lung cancer needing elec- tive surgery in Linyi City Traditional Chinese Medicine Hospital from July, 2015 to January, 2016 were randomly and evenly divided into the control group and the treatment group. The control group was given symptomatic treatment and standard antibiotic treatment on the basis of clinical examination of blood rou- tine, temperature and so on to decide the time to stop using antibiotics. The treatment group was given an- tibiotic treatment under PCT monitoring, and antibiotics application was stopped when the PCT leve was less than 0.5 ng/ml. The time of antibiotics application, the infection incidence of complications and the healing time were compared. Results The time of antibiotics application and the healing time in the treat- ment group was shorter tahn that in the control group, but the time of antibiotics application showed sig- nificant difference （ P 〈0.05）. Conclusion Perioperative monitoring lung cancer patients＇ PCT and guiding the application of perioperative antibiotics can obviously shorten the time of antibiotics application without increasing the incidence of infection complications or prolonging cure time.
出处
《山东医学高等专科学校学报》
2016年第5期361-363,共3页
Journal of Shandong Medical College
基金
临沂市科技发展计划项目(No.201515040)
关键词
降钙素原
肺癌
围手术期
抗菌药物
感染
Procalcitonin
Lung cancer
Perioperative
Antimicrobial agents
Infection
