摘要
目的探讨乌司他丁（UTI）治疗小儿重症肺炎对患儿血清TNF-α、IL-6、IL-8、IL—10水平的影响。方法将50例重症肺炎患儿按住院证单双号分为两组，治疗组24例，对照组26例，治疗组在其他治疗相同的情况下给UTI治疗，5000U／（kg·次），2次／d，连用7d，两组患儿均于治疗前和治疗后第7天抽静脉血采用双抗体夹心酶联免疫吸附法检测血清TNF-α、IL-6、IL-8、IL-10含量。结果治疗前治疗组与对照组患儿血清TNF—α、IL-6、IL-8、IL-10含量（ng／L）分别为221．32±55．21vs．233．4±67．36、122．71±46．47vs．127．54±50．33、153．11±39．23VS．147．32±36．45、43．32±15．11vs．47．41±17．43，两组比较差异均无统计学意义（P〉0．05）。治疗后两组分别为92．43±53．18VS．124．41±46．71、71．67±40．32VS．97．33±44．75、72．91±35．53Vg．95．55±41．33、98．27±21．78VS．81．22±27．11，差异均有统计学意义（P〈0．05）。结论UTI治疗小儿重症肺炎可显著降低患儿血清TNF—α、IL-6、IL-8水平，提高IL-10水平，减轻细胞炎症反应。
Objective To discuss the effect of ulinastatin （UTI） on serum TNF -α. IL -6, IL- 8 and IL - 10 in children with serious pneumonia. Method The children with serious pneumonia were divided into the UTI group （24 cases） and the control group （26 cases） according to the admission number. The UTI group was treated with UTI 5000 U/kg, twice a day for seven days. The serum levels of TNF - α, IL - 6, IL - 8 and IL - 10 were tested by ELISA before and after the treatment in two groups. Results Before the experiment, the serum TNF - α, IL - 6, IL - 8 and IL - 10 in two groups were 221.32±55.21, 122.71 ±46.47, 153. 11 ±39.23, 43. 32 ± 15. 11 and 233.44 ±67.36, 127.54 ±50.33, 147.32 ± 36.45, 47.71 ± 17.43 （t = 0. 678, 0. 345, 0. 530, 0. 928, P 〉0.05）. Seven days later, the levels of TNF - α, IL - 6, IL - 8 and IL - 10 were 92.43 ± 53.18, 71.67 ± 40.32, 72.91 ±35.53, 98.27 ±21.78 and 124.47 ±46.71, 97.33 ±44.75, 95.55 ±41.33, 81.22±27.11 （t=2.222, 2.080, 2.027, 2.389, P〈0. 05）. Conclusion Treatment with UTI can decrease TNF- α, IL-6, IL-8 in serum, meanwhile raise the level of IL- 10.
出处
《中国急救医学》
CAS
CSCD
北大核心
2016年第10期940-942,共3页
Chinese Journal of Critical Care Medicine
