摘要
目的观察及研究外伤性肝损伤患儿保守治疗前后血流变及血清视黄醇结合蛋白(RBP)、高尔基体蛋白73(GP73)、一氧化氮(NO)、白介素(IL)的变化情况。方法选取本院2013年1月至2015年3月间收治的22例外伤性肝损伤患儿为观察组,同时期的22名健康同龄儿童为对照组,将观察组治疗前和治疗后12、24、48、72及96小时和对照组的血流变及血清RBP、GP73、NO、IL水平进行检测,然后将两组的检测结果进行比较。结果观察组治疗前和治疗后12、24、48、72及96小时的血流变及血清GP73、NO、IL水平均高于对照组,而血清RBP则低于对照组,观察组中治疗后24h的血流变及血清GP73、NO高于其他时间段,血清RBP低于其他时间段,血清IL则在治疗后48h高于其他时间段,P均<0.05。结论外伤性肝损伤患儿保守治疗前后血流变及血清RBP、GP73、NO、IL的变化较大,应针对其变化情况给予密切监测及针对性干预。
Objective To observe and study the change of hemorheology and serum retinol-binding protein （RBP）,Golgi body protein 73 （GP73） ,nitric oxide （NO） ,interleukin（IL） of children with traumatic liver injury before and after the expectant treatment. Methods 22 children with traumatic liver injury in our hospital from January 2013 to March 2015 were selected as observation group,22 healthy children at the same time were selected as the control group,then the hemorheology and serum RBP,GP73, NO,IL of observation group before the treatment and at 12h,24h, 48h,72h and 96h after the treatment and control group were detected,and the results of two groups were compared. Results The hemorheology and serum GP73,NO,IL of observation group before the treatment and at 12h,24h,48h,72h and 96h after the treatment were all higher than those of control group,while the serum RBP was lower than that of control group ,and the hemorheology and serum GP73 ,NO of observation group at 24h after the treatment were all higher than those at other time,the serum RBP were lower than those at other time,serum IL at 48h after the treatment were higher than those at other time,all P〈0.05. Conclusion The change of hemorheology and serum RBP, GP73,NO,IL of children with traumatic liver injury before and after the expectant treatment were great,and they should be paid to close monitoring and targeted intervention according to the change situation.
出处
《浙江创伤外科》
2016年第5期828-830,共3页
Zhejiang Journal of Traumatic Surgery
