摘要
目的：探讨抗SSA抗体阳性患者的临床特点及神经影像学特征,提高医生对该抗体临床意义的认识。方法：对我院2015年3月15日至2016年1月15日抗SSA抗体阳性患者的临床资料进行回顾性分析。结果：共308例抗SSA抗体阳性患者,其中男77例,女231例,男女1∶3。35-50岁组构成比高于其它组;系统性红斑狼疮患者有106例（34.42%）,干燥综合征患者有52例（16.88%）,类风湿性关节炎患者有10例（3.25%）,视神经脊髓炎患者有7例（2.27%）;50例行影像学检查中10例正常,26例白质变性,9例缺血样改变,5例颈髓病变。54例患者合并神经系统损害。结论：抗SSA抗体阳性不能与干燥综合征划上等号。抗SSA抗体阳性患者更易合并神经系统损害,包括中枢性（脑、脊髓）损害及周围性（周围神经、肌肉）损害,神经影像学表现以皮层下白质及室旁白质病变为主。
Objective： To investigate clinical and neuroimaging features of patients with positive anti-SSA antibody on,so as to improve clinician awareness of the significance. Method： Hospitalized patients with positive anti-SSA antibody during March 15,2015 and January 15,2016 of our hospital were enrolled. Results： Among 308 patients enrolled,77 were males and 231 females,with a male to female ratio 1∶ 3. Those being 35-50 year-old constitute a big portion. Clinical characteristics of patients varied,including 106 cases of SLE（ 34. 40%）,52 cases of SS（ 16. 80%）,10 cases of RA（ 3. 20%）. A total of 50 patients underwent MRI/CT scan,10 cases were negative,26 cases with white matter lesions（ 52%）. Also,we found 54 cases with neurologic involvement,including central nervous system involvement in 24 cases,peripheral nervous system involvement in 30 cases. Conclusion： Positive anti-SSA antibody are not necessarily indicating SS only. According to our study,positive anti-SSA antibody was much more common in patients with SLE. Neurological imaging mainly showed white matter and subcortical white matter lesions. This antibody needs a comprehensive examination of the autoantibodies and comprehensive analysis of clinical manifestations.
出处
《东南大学学报（医学版）》
CAS
北大核心
2016年第5期723-726,共4页
Journal of Southeast University(Medical Science Edition)
基金
南方医院院长基金(3101030102)
