摘要
目的观察疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法将80例患者按随机数字表法分为治疗组41例和对照组39例,两组均给予常规对症治疗。治疗组在常规治疗基础上应用疏风解毒胶囊口服,两组疗程均为14 d。结果治疗组总有效率为85.37%,对照组为66.67%,两组比较,差异有统计学意义(P<0.05)。治疗后,两组患者血清IL-8和TNF-α水平均较治疗前均显著降低(P<0.05),且治疗组IL-8和TNF-α水平明显低于对照组(P<0.05)。结论联合疏风解毒胶囊治疗能更好降低COPD急性加重期血清中IL-8和TNF-α水平,提高临床疗效。
Objective： To observe the influence of Shufeng Jiedu Capsule on IL-8 and TNF-α of patients with acute exacerbation of chronic obstructive pulmonary disease. Methods： 80 patients with acute exacerbation of chronic obstructive pulmonary disease ,by random number table ,were divided into the treatment group （41 cases） and control group （39 cases）. All patients were given conventional treatment（anti-infection, spasmolysis and asthma, phlegm and oxygen,etc.）. The treatment group was given Shufeng Jiedu Capsule on the basis of conventional treatment. The course of treatment was 14 days. IL-8 and TNF-α in patients＇ serum were examined in pre therapy and post-treatment, and clinical efficacy was evaluated. Results： The total effective rate in the treatment group （85.37%） was better than that of the control group （66.67%）. The difference was statistically significant （P〈 0.05）. The difference on the concentration of serum IL-8 and TNF-α of patients between the two groups was not statistically significant before the treatment（P〉 0.05）. The concentration of serum IL-8 and TNF-α of patients in both groups decreased significantly after the treatment（P〈 0.05）. The concentration of serum IL-8 and TNF-α of patients in the treatment group was obviously lower than that of the control group after treatment（P〈 0.05）. Conclusion： Shufeng Jiedu Capsule combined with conventional treatment can bring the concentration of serum IL-8 and TNF-α of patients down, and improve the clinical efficacy.
出处
《中国中医急症》
2016年第11期2171-2173,共3页
Journal of Emergency in Traditional Chinese Medicine
