摘要
目的调查广东省部分人群(动物从业人员和一般人群)的多重耐药金葡菌(multidrug-resistant S.aureus,MDRSA)携带情况,并分析菌株的耐药性。方法对研究对象进行问卷调查和鼻拭子采样,对金葡菌进行药敏试验,分析方法采用2检验。结果动物从业人员中金葡菌、MDRSA、甲氧西林耐药金葡菌(methicillin-resistant S.aureus,MRSA)的携带率均高于对照人群(分别为13.3%vs 9.3%;9.5%vs 3.4%;7.0%vs 1.4%;均有P<0.01)。金葡菌对青霉素、克林霉素、四环素和红霉素的耐药率较高,MDRSA主要耐药模式是同时对克林霉素、红霉素、四环素耐药。除了青霉素外,动物从业人员金葡菌对各类抗生素的耐药率均高于对照人群;MRSA菌株对各类抗生素的耐药率均高于甲氧西林敏感金葡菌。结论本研究提示职业性动物接触可能导致从业人员感染耐药细菌。
Objective To investigate the carriage rate and antibiotic resistance of muhidrug-resistant S. aureus among animal-related workers and general population in Guangdong Province. Methods We surveyed the study population by face-to-face questionnaire and nasal swab sampling. All S. aureus isolates were tested for antibiotic susceptibility test, and the data were analyzed by ehi-squared test. Results The carriage rates of S. aureu~, multidrug-resistant S. aureus and methieillin-resistant S. aureus （MRSA） were higher in animal-related workers than in controls （ 13.3% vs 9. 3% ; 9. 5% vs 3.4% ; 7.0% vs 1.4% ; all P 〈0. 01 ）. The rates of S. aureus isolates showed high levels of resistance to penicillin, elindamyein, tetracycline and erythromycin, and the dominant muhidrug resistance pattern of multidrug-resistant S. aureus isolates were mainly resistant to clindamycin, erythromycin and tetracycline. S. aureus strains isolated from animal- related workers showed higher levels of resistances to antibiotics, except for penicillin, than those from general population. The antibiotic-resistant rate was higher in MRSA isolates than in methicillin-sensitive S. aureus isolates. Conclusions This study suggests that occupational animal contact may lead to the infection of drug resistant bacteria.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2016年第10期1039-1042,共4页
Chinese Journal of Disease Control & Prevention
基金
广东省教育厅青年创新人才类项目(广东药学院创新强校工程资助
2014KQNCX138)
佛山市顺德区医学科研基金(2015A005)
关键词
葡萄球菌
金黄色
职业暴露
流行病学方法
Staphylococcus aureus
Occupational exposure
Epidemiologic methods
