摘要
目的：了解支气管哮喘（简称哮喘）患儿血清25-羟维生素D3[25（OH）D3]水平及其与肺功能、呼出气一氧化氮（ FeNO）的关系，为哮喘的治疗提供新的策略。方法选取门诊6~14岁初诊哮喘患儿112例为观察组，选取同期在儿童保健科体检的6~14岁健康儿童78例为对照组，通过电化学发光法检测两组患儿血清中25（ OH）D3的含量，检测哮喘患儿呼气峰流速（ PEF）、第1秒用力呼气容积（ FEV1）、呼气峰流速占预计值百分比（ PEF％ pred ）、第1秒用力呼气容积占预计值百分比（ FEV1％ pred），对观察组患儿进行FeNO检测。对25（ OH）D3与PEF％ pred、FEV1％ pred、FeNO的相关性进行分析。结果观察组的维生素 D 缺乏、不足比例均高于对照组（χ2＝7.78，P ﹤0.01）；PEF％ pred、FEV1％ pred的值随血清25（OH）D3水平的下降而降低（F＝28.12、29.56，P均﹤0.05）， FeNO值随血清25（OH）D3水平的下降反而升高（F＝15.65，P﹤0.05）。结论维生素D缺乏或不足与儿童哮喘相关，与哮喘患儿肺功能下降有关，且可增加哮喘患儿气道炎症水平。
Objective To determine the serum 25 hydroxy vitamin D3[25（OH）D3]levels in chil-dren with bronchial asthma and its relationship with lung function,fraction of exhaled nitric oxide（ FeNO）. Methods Totally 112 children with asthma aged 6 years to 14 years old were selected as the study group, meanwhile 78 healthy children aged 6 years to 14 years old were selected as the control group,serum 25 （ OH）D3 was determined using the electrochemical luminescence method. Lung function was measured, which included peak expiratory flow（ PEF）,forced expiratory volume in one second（ FEV1 ）,percentage of PEF in predicted value（ PEF% pred）,percentage of FEV1 in predicted value（ FEV1% pred）. FeNO of the study group was measured. The relationship between serum 25（ OH）D3 and PEF% pred,FEV1% pred,FeNO were all analyzed. Results The proportion of vitamin D deficiency and insufficiency in the study group were higher than those in the control group（χ2 =7. 78,P﹤0. 01）. The values of PEF% pred and FEV1% pred were decreased with the decreasing of the 25（OH）D3 levels（F=28. 12,29. 56,P﹤0. 05）,FeNO values were in-creased with the decreasing of the 25（OH）D3 levels（F=15. 65,P﹤0. 05）. Conclusion Vitamin D defi-ciency or insufficiency is related to asthma in children. It is associated with the decrease of lung function,and can increase the level of airway inflammation in children with asthma.
出处
《中国小儿急救医学》
CAS
2016年第9期613-615,630,共4页
Chinese Pediatric Emergency Medicine
