摘要
目的了解乡镇手足口病病原分布特征和流行情况,为疾病防控提供科学依据。方法采集2013年-2015年乡镇卫生院首次就诊临床诊断手足口病病例标本312份,应用实时荧光PCR方法检测手足口病肠道病毒通用型（EV）、肠道病毒71型（EV71）、柯萨奇病毒CVA16、CVA6、CVA10型。结果共采集标本312份,肠道病毒检出率为58.65%。2013年优势病原为CVA6,占57.89%;2014年优势病原为CVA16,占38.37%;2015年优势病原为CVA6,占32.20%。高发年龄为1岁-5岁;发病人群以托幼儿童和散居儿童为主,托幼儿童阳性率高于散居儿童,差异具有统计学意义（P〈0.05）。结论 CVA6在2013年-2015年海盐县手足口病病原谱中占有优势,CVA10也有潜在威胁。建议手足口病常规监测中增加对CVA6和CVA10及其他未定型肠道病毒的监测,加大重点人群的监管力度,有效控制重症病例和聚集性病例的发生。
Objective To understand the etiologic and epidemiological characteristics of hand- foot and mouth disease（ HFMD） in villages and towns,so as to provide scientific basis for the disease control and prevention. Methods 312 specimens were collected from the clinical diagnosed HFMD cases in the hospitals of villages and towns,and the EV,EV71,CVA16,CVA6,CVA10 were detected by real- time fluorescent quantitative RT- PCR. Results A total of 312 samples were collected,and the detection rate of intestinal virus was 58. 65%. The dominant pathogen in 2013,2014 and 2015 were CVA6,CVA16 and CVA6,accounting for 57. 89%,38. 37%,32. 20% respectively. The cases were mainly concentrated in the 1- 5age group,who were mainly scattered children and kindergarten children,and the difference of positive rate was statistically significant（ P 〈 0. 05）. Conclusion The predominant type causing HFMD in Haiyan could be CVA6 from 2013 to 2015,and CVA10 also has potential dangers. It is necessary to enhance the monitoring of CVA6 and CVA10 and unclassified enterovirus,and to enhance the supervision on key crowd,so as to effectively control the occurrence of severe cases and clustered cases.
作者
周晓红
张孝艳
徐佩华
孙明华
朱晓微
ZHOU Xiao-hong ZHANG Xiao-yan XU Pei-hua SUN Ming-hua ZHU Xiao-wei(Haiyan Center for Disease Control and Prevention, Haiyan , Zhejiang 314300, China)
出处
《中国卫生检验杂志》
CAS
2016年第20期2982-2984,共3页
Chinese Journal of Health Laboratory Technology
关键词
乡镇
手足口病
肠道病毒
Villages and towns
Hand-foot and mouth disease
Enterovirus
