摘要
目的探讨药物热的临床表现、发生机制、特点及规律,为临床合理、安全用药提供参考。方法通过检索中国知网(CNKI)、万方数据库、维普资讯网公开发表的有关药物热的医药文献,对符合条件的文献进行分类及汇总。结果共检索到文献356篇,原始病例422例。发生药物热的药物主要是抗菌药物152例(36.02%),中药制剂66例(15.64%);主要给药途径是静脉滴注,共282例(66.82%);343例(81.28%)病例除发热外还伴发其他症状,以全身性损害(如寒战、全身发抖)和皮肤损害(如皮疹)为主;275例(65.16%)病例于用药7 d天内出现药物热,停用可疑药物后302例(71.56%)病例在3 d内体温恢复正常。结论治疗药物热最好的办法就是停用可疑药物。临床要正确认识并重视药物热,加强合理用药,减少药品不良反应的发生,提高临床合理安全用药的水平。
Objective To understand the clinical manifestations of drug fever, to explore the mechanism, characteristics and rules of drug fever, to provide reference for clinical rational drug use. Methods Medical literature related to drug fever in CNKI （CNKI）, Wanfang database and VIP were retrieved, and the ones that met the requirements were classified and summaried. Results A total of 356 arti- cles were retrieved and 422 cases were original. Drug fever drugs were mainly antibacterials （152 cases, 36. 02% ）, Chinese medicine preparation （66 cases, 15.64% ）; the route of administration was mainly intravenous injection （282 cases, 66.82% ）; 343 cases （81.28%） accompanied with other symptoms besides fever, which were mainly systemic damage （shiver, whole body shaking） and skin lesions （rash）; 275 cases （65.16%） occurred drug fever within 7 d of drug use, and in 302 cases（71.56% ） the body temperature re- turned to normal within 3 d after discontinuation of suspicious drug. The best way to treat the drug fever was to stop using the sus- pected drug. Conclusion The clinical need to correctly understand and pay attention to drug fever, strengthen the rational use of drugs, reduce the incidence of adverse drug reactions, improve the level of clinical rational drug safety.
出处
《中国药业》
CAS
2016年第21期74-78,共5页
China Pharmaceuticals
关键词
药物热
发热
药品不良反应
合理用药
drug fever
fever
adverse drug reaction
rational drug use
