期刊文献+

慢性粒细胞白血病髓外淋巴结急性变一例并文献复习 被引量:3

Chronic myelogenous leukemia extramedullary blast in lymph node:report of one case and review of literature
原文传递
导出
摘要 目的:提高对慢性粒细胞白血病(CML)急性变的认识。方法报道1例以髓外淋巴结为首发的 CML 急性变患者,结合该例患者的实验室检查、骨髓及淋巴结免疫组织化学检测、遗传学检测等结果进行综合分析。结果该例患者曾被误诊为淋巴母细胞性淋巴瘤,骨髓表现为典型的 CML 慢性期,淋巴结表现为急变期,大部分呈淋巴母细胞分化,少量呈髓系分化。具有特征性费城染色体及 bcr-abl 融合基因阳性。结论 CML 慢性期患者发生髓外淋巴结急性变少见,正确诊断需结合临床,并综合应用形态学、细胞遗传学、免疫组织化学及分子生物学等多种诊断技术。
出处 《白血病.淋巴瘤》 CAS 2016年第10期615-617,共3页 Journal of Leukemia & Lymphoma
  • 相关文献

参考文献5

二级参考文献80

  • 1吴彬,周淑芸,刘晓力.干扰素-α对K562细胞基因表达谱的调控研究[J].中国实验血液学杂志,2005,13(5):746-750. 被引量:3
  • 2邓明凤,王昌富,张万胜,李琳芸,彭长华,陈永玲.慢性髓细胞白血病患者染色体分析及bcr/abl融合基因转录本定量的临床意义[J].临床检验杂志,2006,24(3):179-181. 被引量:5
  • 3Geyer R, Szeto M, Craven A, et al. Stromal cell-derived secreted factors contribute to the innate Imatinib resistance of leukemia stem cells in a genetically defined murine model of chronic myeloid leukemia blast crisis. Blood, 2010, 116: Abstract No.204.
  • 4Tabe Y, Jin L, Zhou YX, et al. Role of stromal microenvironment in non-pharmacological resistance of CML to tyrosine kinase inhibitors through lyn / CXCR4 interactions in lipid rafts. Blood, 2010, 116: Abstract No.3390.
  • 5Gemani D, Tobin LA, Singh A, et al. The dark side of NRF2: upregulation of NRF2 as a mechanism for resistance to imatinib in CML. Blood, 2010, 116: Abstract No.3401.
  • 6Hughes TP, Hochhaus A, Saglio G, et al. ENESTnd update: continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP). Blood, 2010, 116: Abstract No.207.
  • 7Hochhaus A, Saglio G, Larson RA, et al. Nilotinib lowers the incidence of bcr-abl mutations and improves the molecular response kinetics compared with imatinib in patients (Pts) with newly diagnosed chronic myeloid leukemia (CML). Blood, 2010, 116: Abstract No. 3431.
  • 8Rosti G, Castagnetti F, Gugliotta G, et al. Excellent outcomes at 3 years with nilotinih 800 mg daily in early chronic phase, Ph+ chronic myeloid leukemia (CML): results of a phase 2 GIMEMA CML WP clinical trial. Blood, 2010, 116: Abstract No.359.
  • 9Conneally E, Swords RT, Giles FJ, et al. Nilotinib 300 mg twice daily as first line treatment of Ph-positive chronic myeloid leukemia in chronic phase: updated results of the ICORG 0802 phase 2 study with analysis of the genexpert system versus IS BCR-ABL RQ PCR. Blood, 2010, 116: Abstract No.3427.
  • 10Giles FJ, Yin O, Chia YL, et al. Nilotinib exposure-response analysis in patients with imatinib-resistant or -intolerant chronic myeloid leukemia (CML). Blood, 2010, 116: Abstract No.890.

共引文献33

同被引文献19

引证文献3

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部