摘要
目的探讨血浆同型半胱氨酸(Hcy)、内皮素-1(ET-1)与血管性痴呆(VaD)患者认知功能的关系。方法选取VaD患者50例(Va D组)、非痴呆性脑梗死患者55例(脑梗死组)及健康者46例(正常组),观察各组血浆中Hcy、ET-1、叶酸及维生素B_(12)水平。结果与正常组比较,VaD组和脑梗死组血浆Hcy、ET-1水平升高(P<0.01),而叶酸和VitB_(12)水平降低(P<0.01)。在Va D患者中,中、重度痴呆者血浆Hcy、ET-1水平明显高于轻度痴呆者(P<0.05),而叶酸和VitB_(12)水平降低(P<0.05)。Hcy与ET-1水平呈明显正相关(r=0.221,P<0.05)。结论血浆Hcy和ET-1水平可作为判断VaD严重程度的指标。
Objective To study the relationship between plasma homocysteine （Hcy） and endothelin-1 （ET-1） levels and cognitive function in vascular dementia （VD）. Methods Plasma levels of Hcy, ET-1, folic acid （FA） and vitamin B12 were detected in 50 patients with VD, 55 with non-demented cerebral infarction （NDCI）, and 46 healthy controls, impairment. Results Compared with control group, Hcy and ET-1 levels were increased but FA and vitamin B12 levels decreased （P〈0.01） in VD and NDCI groups. Hcy and ET-1 levels were higher but FA and vitamin B12 levels lower in moderate and severe dementia than in mild dementia （P〈0.05） in VD group. A positive correlation was present between Hcy and ET-1 contents （r=0.221, P〈0.05）. Conclusion Plasma levels of Hcy and ET-1 may serve as indexes for evaluating VD severity.
出处
《广东医学院学报》
2016年第4期347-350,共4页
Journal of Guangdong Medical College
基金
佛山市卫生和计生局医学科研课题(No.2015044)
