摘要
目的探讨原发性舍格伦综合征(primary Sjgeren’s syndrome,p SS)患者血清中肿瘤坏死因子(TNF-α)、B细胞刺激因子(BAFF)、细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)的表达意义,为p SS的临床治疗提供实验依据。方法选择经病理确诊的p SS患者50例,酶联免疫吸附试验(ELISA)检测患者血清中TNF-α、BAFF、ICAM-1、VCAM-1的含量,并利用SPSS软件包对数据进行统计学分析。结果 p SS患者血清中TNF-α、BAFF、ICAM-1、VCAM-1的含量较正常对照组显著升高(P<0.05)。结论细胞因子TNF-α、BAFF、ICAM-1、VCAM-1可能参与了p SS的发生发展过程,其相互作用关系有待进一步研究。
Obejetive To explore the expression of TNF-α,BAFF,ICAM-1 and VCAM-1 in the serum of patients with primary Sjgeren＇s syndrome and to provide experimental basis for clinical treatment of p SS. Methods Fifty primary Sjgeren＇s syndrome patients were diagnosed by pathological examination. Serum expression levels of TNF-α,BAFF,ICAM-1 and VCAM-1 were detected by enzyme linked immunosorbent assay（ ELISA）. The software SPSS was used for statistical analysis. Results The expression levels of TNF-α,BAFF,ICAM-1 and VCAM-1 obviously increased in serum of p SS patients compared with healthy subjects（ P 0. 05）. Conclusion TNF-α,BAFF,ICAM-1 and VCAM-1 may be involved in the occurrence and development of p SS,and the exact interactions between them still need further research.
作者
邓剑兰
范媛
DENG Jianlan FAN Yuan(Jiangsu Key Laboratory of Oral Diseases, Nanfing Medical University, Nanjing 210029, China)
出处
《口腔医学》
CAS
2016年第11期1011-1013,共3页
Stomatology
基金
国家自然科学基金(81170961)
江苏高校优势学科建设工程资助项目(2014-37)
