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TNF-α和IL-10与重症脓毒症患者预后的相关性研究 被引量:12

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摘要 目的:探讨血清肿瘤坏死因子-α(TNF-α)和白介素-10(IL-10)浓度变化在重症脓毒症患者预后评估中的应用。方法:采用酶联免疫吸附法C(ELISA法)对97例重症脓毒症患者入ICU时的血清TNF-α、IL-10进行测定,根据患者预后效果将97例患者分为生存组和死亡组,对比分析两组TNF-α和IL-10的变化;同时选取同期健康体检者30例设对照,观察脓毒症组与对照组血清TNF-α和IL-10的水平差异。结果:重症脓毒症患者入ICU首日TNF-α和IL-10水平明显高于健康对照组(P<0.05);死亡组存活组比较,TNF-α和IL-10的表达明显增加,差异有统计学意义(P<0.01)。结论:TNF-α和IL-10在重症脓毒症的发生发展中起着重要作用,为脓毒症患者预后评估及治疗的选择提供理论依据。
出处 《陕西医学杂志》 CAS 2016年第12期1600-1601,共2页 Shaanxi Medical Journal
基金 河北省卫生厅青年基金项目(20120158) 河北省张家口市科技计划项目(12110051D)
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