摘要
目的观察匹多莫德辅助舌下免疫疗法治疗小儿变应性鼻炎伴哮喘的疗效,为今后临床更有效治疗该疾病提供参考和借鉴。方法前瞻性选取宁波大学医学院附属医院小儿内科2013年1月~2015年1月期间确诊的60例小儿变应性鼻炎伴哮喘患儿,随机数字表法为对照组和治疗组,每组30例。对照组采用常规治疗^+舌下免疫治疗,治疗组采用常规治疗+舌下免疫治疗+匹多莫德,观察2组患儿病情改善、免疫功能、炎症因子水平、肺功能改善情况以及不良反应发生情况。结果 2组患儿治疗后鼻炎和哮喘病情均明显减轻,且治疗组改善情况较对照组更为显著(P<0.05),均未发生严重不良反应;治疗组患儿免疫功能(Ig M、Ig G、Ig A、CD3^+、CD4^+、CD4^+/CD8^+),炎症因子水平包括C-反应蛋白(C-reactive protein,CRP)、酶联免疫吸附法检测白细胞介素-8(interleukin-8,IL-8)、肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α),肺功能包括一秒钟用力呼气容积(forced expiratory volume in one second,FEV1)、最大呼气峰流速(peak expiratory flow rate,PEF)、用力呼气25%流速(25%of peak expiratory flow rate,PEF25)、用力呼气50%流速(PEF_(50))、用力呼气75%流速(PEF_(75))改善情况明显优于对照组(P<0.05)。结论匹多莫德联合舌下免疫治疗小儿变应性鼻炎伴哮喘可明显提高患儿免疫功能,减轻炎症反应,促进肺功能改善,达到改善临床症状的治疗期望,且无严重不良反应。
Objective To observe the therapeutic effect of pidotimod in the treatment of allergic rhinitis and asthma in children,and provide reference for the clinical treatment of the disease in the future. Methods 60 cases of children with allergic rhinitis and asthma diagnosed in our hospital from January 2013 to January 2015,60 cases of children with asthma were selected and divided into two groups by the method of random digital table,30 cases in each group,the control group received routine therapy ＋ sublingual immunotherapy,the treatment group were treated with routine therapy ^＋sublingual immunotherapy ＋ pidotimod,disease improvement,immune function,inflammatory factors,lung function and adverse reactions between the two groups of children were compared. Results The rhinitis and asthma severity in two groups after treatment in children were significantly relieved,and the treatment group improved more significantly than control group（ P〈0. 05）,there was no serious adverse reactions in both groups. The improvement of immune function（ IgG,IgA,IgM,CD4^＋,CD3^＋,CD4^＋/ CD8^＋） and levels of inflammatory factors（ CRP,IL-8,TNF-α） and lung function（ FEV1,PEF,PEF25,PEF50,PEF75） in the treatment group was significantly better than those of the control group（ P〈0. 05）. Conclusion Pidotimod combined with sublingual immunotherapy in children with allergic rhinitis and asthma can significantly improve the immune function,reduce inflammatory reaction,promote lung function and clinical symptoms,with no serious adverse reactions.
出处
《中国生化药物杂志》
CAS
2016年第10期88-91,94,共5页
Chinese Journal of Biochemical Pharmaceutics
关键词
匹多莫德
小儿
变应性鼻炎
变应性哮喘
舌下免疫治疗
疗效
pidotimod
children
allergic rhinitis
allergic asthma
sublingual immunotherapy
efficacy
