摘要
目的探讨桥本甲状腺炎（HT）与甲状腺乳头状癌（PTC）之间的关系.方法收集2000年1月-2015年6月6234例甲状腺结节手术患者的临床资料,术后经病理确诊为PTC1016例,依据合并HT与否分为合并HT及未合并HT两组,对其临床特征进行比较分析.结果（1）6234例患者中8.66%合并HT（540/6234）.与未合并HT者相比,合并HT者女性多见、年龄更小、PTC检出率更高（P〈0.01）.（2）1016例PTC患者中,与未合并HT者相比,合并HT者女性更多见、平均年龄更小、高发年龄36-55岁,多发癌灶更常见、微小癌（≤1cm）比例更高,原发灶包膜外侵犯比例、淋巴结转移率、TNM分期Ⅲ/Ⅳ期比例及BRAF突变率更低（P〈0.01或P〈0.05）.合并HT与PTC的发生呈正相关（P〈0.01）.结论HT与PTC的发生呈正相关.PTC合并HT患者女性更多见、预后更好.
Objective To investigate the relationship of Hashimoto's thyroiditis(HT) and papillary thyroid cancer(PTC). Methods Clinical data of 6 234 patients with thyroid nodule operation were collected from January 2000 to June2015. PTC was pathologically confirmed after operation in 1 016 cases. Patients were divided into PTC combined with HTgroup and PTC without HT group. The clinical features were compared and analyzed between two groups. Results(1) In6 234 patients, 8.66%(540/6 234) patients were complicated with HT. Compared with patients without HT, there were morefemale patients, more younger patients and higher incidence of PTC in this group of patients.(P < 0.01).(2) In 1 016 patientswith PTC, compared with patients without HT, there were more female patients combined with HT, more patients with loweraverage ages, and high incidence of age from 36 to 55 years old, multiple cancers were more common, higher proportion ofsmall cancer(≤1 cm), and lower extracapsular extension ratio, lower rate of lymph node metastasis, and lower ratio of TNMstage Ⅲ/Ⅳ and lower BRAF mutation rate(P < 0.05 or P < 0.01). There was a positive correlation between the occurrence ofHT and PTC(P < 0.01). Conclusion There is a positive correlation between the occurrence of HT and PTC. In patientscombined with HT and PTC, there are more female ones, and whose prognosis are better.
出处
《天津医药》
CAS
2016年第11期1311-1314,共4页
Tianjin Medical Journal
关键词
桥本病
甲状腺肿瘤
癌
乳头状
甲状腺结节
Hashimoto disease
thyroid neoplasms
carcinoma
papillary
thyroid nodule
