摘要
目的观察硒、碘对自身免疫性甲状腺炎(AIT)患者TPOAb及TGAb的影响。方法选取就诊于唐山市工人医院内分泌科2015年11月—2016年5月收治的196例AIT患者,符合本研究入选标准的有93例AIT(血清TPOAb≥200IU/ml,血清TGAb≥200IU/ml,TSH<10μIU/ml,尿碘≥200μg/L,无明显自身免疫性疾病、无明显肝肾疾病),在征得患者及家属同意情况下且根据病情,将其分为观察组和对照组,观察组包括补硒组(A组)32例,平均年龄(35.2±16.48)岁、补硒加适碘饮食组(B组)31例,平均年龄(39.4±14.27)岁,对照组30例,平均年龄(37.0±17.32)岁,给予常规治疗,比较三组患者分别于治疗前与治疗6个月后甲状腺功能及自身抗体变化等。结果三组患者分别于治疗前与治疗6个月后相比较,FT3、FT4、TSH水平未有明显改变,差异无统计学意义(P>0.05);A、B二组患者TPOAb水平下降,差异均有统计学意义(t_(A组)=7.67,t_(B组)=10.73,PA、B<0.05);TGAb水平虽有下降但差异无统计学意义(t_(A组)=1.18,t_(B组)=1.05,PA、B>0.05);对照组患者TPOAb升高显著有统计学意义(t=5.63,P<0.05),TGAb无明显改变,差异无统计学意义(P>0.05);对A、B二组患者进行组间比较TPOAb水平无明显改变,差异无统计学意义(t=1.82,P>0.05)。结论补硒可有效降低AIT患者TPOAb水平,缓解自身免疫状态。
Objective To investigate the effects of selenium and iodine on TPOAb and TgAb in patients with autoimmune thyroiditis. Methods Two hundred cases of patients with AIT were selected in department of endocrinology, Tangshan worker hospital in November 2015 to May 2016. Among them, 93 cases of AIT meet the criteria for this studyn （TPOAb 200 IU/ml, or serum TgAb acuity 200IU/ml, TSH〈 10muIU/ml, urine iodine 200μg/L, or no obvious autoimmune disease, no significant liver and kidney diseases）. Under the consent of the patient and family, all patients were randomly divided into treatment group and control group according to the condition. The treatment group included selenium group （group A,32 cases）, the average age was （35.2 ± 16.48} years, selenium plus normal iodine diet group （group B,32cases）, the average age was （39.4 ± 14.27） years. While 30 cases in the control group, the average agewas （37.0 ± 17.32） years old, given conventional treatment, more three groups of patients before treatment and treatment after 6 months of treatment and thyroid autoantibodies changes. Results Three groups of patients before and after treatment were compared to 6 months of treatment, FT3, FT4, TSH levels were no significant change, no statistically significant difference （P〉0.05） ;group A and group B of patients with thyroid peroxidase enzyme antibody （TPOAb） levels decreased, the difference was statistically significant （tA = 7. 67 ,tB = 10. 73,PA.B 〈0. 05）. Thyroglobulin antibody （ TgAb） levels had decreased but the difference was not statistically significant （tA = 1.18,tB = 1.05,PA, B〉0. 05）, The control group was significantly elevated in patients with TPOAb were statistically significant （t = 5.63,P〈0.05）, TGAb no significant change was not statistically significant （P〉0.05） ; for A, B two groups of patients were compared between groups TPOAb levels did not change significantly, the difference was not statistically significant （t = 1.82,P〉0.05）. Conclusion Selenium supplementation can effectively reduce TPOAb levels in patients with AIT, alleviate autoimmune condition.
出处
《中国煤炭工业医学杂志》
2016年第11期1557-1560,共4页
Chinese Journal of Coal Industry Medicine
基金
基金项目:唐山市甲状腺疾病诊治科技创新团队(编号:15130211C)
