摘要
目的:探讨羧甲基纤维素钠眼液联合重组人表皮生长因子(recombinant human epidermal growth factor,rh EGF)对白内障患者超声乳化术后干眼的治疗效果。方法:选取2015-10/2016-05于我院接受治疗的白内障超声乳化术后干眼症患者150例150眼,随机分为试验组(75例75眼)和对照组(75例75眼)。试验组采用羧甲基纤维素钠眼液联合rh EGF治疗,对照组采用羧甲基纤维素钠眼液单药治疗。记录患者治疗前及治疗后1wk,1mo的干眼主观症状评分、角膜荧光素染色(FL)情况、泪液分泌试验(SⅠt)以及泪膜破裂时间(BUT)。结果:治疗前,两组患者的干眼主观症状、泪膜稳定性指标(BUT、FL、SⅠt)比较差异无统计学意义(P>0.05)。治疗后,两组患者随时间延长各指标均有明显改善,差异有统计学意义(P<0.01),试验组较对照组干眼主观症状更轻,差异有统计学意义(P<0.05)、BUT明显延长,差异有统计学意义(P<0.05)、FL明显减少,差异有统计学意义(P<0.05)、SⅠt明显增加,差异有统计学意义(P<0.05)。结论:羧甲基纤维素钠眼液联合rh EGF可有效改善白内障术后干眼症状,恢复泪膜稳定性,其疗效显著优于单独使用羧甲基纤维素钠眼液。
AIM：To explore the clinical effect of carboxymethylcellulose sodiumeye drops and recombined human epidermal growth factor（ rh EGF） on the cataract patients with dry eye after phacoemulsification.METHODS： A total of 150 patients with cataract（ 150eyes） referred to our hospital fromOct. 2015 to M ay 2016 were randomly divided into trial group and control group,75 cases in each group. All patients after cataract phacoemulsification were received the treatment of dry eye according to different groups. In treatment goup,patients were treated by carboxymethylcellulose sodiumeye drops and rh EGF. In control group, patients were treated by carboxymethylcellulose sodiumeye drops. The subjective dry eye symptoms, as well as fluorescein staining（ FL）,Schirmer Ⅰ test（ SⅠt） and tear break-up time（ BUT） were recorded before treatment,1wk,1mo after treatment.RESULTS： Before treatment,there were no significant differences between groups in the subjective dry eye symptoms and the results of BUT,FL and SⅠt（ P〉0. 05）.After treatment,all the index in two groups significantly improved over time（ P 〈0. 01）,and all the index were better in treatment group than those in control group（ P〈0. 05）. The treatment group had less severe subjective dry eye symptoms,longer BUT,fewer FL,and more SⅠt.CONCLUSION： Combined use of carboxymethylcellulose sodiumeye drops and rh EGF can relieve the dry eyesymptoms and maintain the tear filmstable after phacoemulsification effectively. Therapeutic effects of combined utilization are better than that of carboxymethylcellulose sodiumeye drops used alone.
出处
《国际眼科杂志》
CAS
2016年第12期2247-2249,共3页
International Eye Science
关键词
白内障超声乳化术
干眼症
羧甲基纤维素钠眼液
重组人表皮生长因子
phacoemulsification cataract surgery
dry eye symptoms
carboxymethylcellulose sodiumeye drops
recombined human epidermal growth factor
