摘要
目的探讨结直肠癌肝转移根治术后远期疗效的影响因素。方法回顾性分析2010年8月至2012年8月我院收治的68例结直肠癌肝转移患者的临床资料,分析各临床特征与3年无瘤生存率及累积生存率的关系,并通过建立Cox比例风险模型多因素分析无瘤生存率及累积生存率的危险因素。结果无瘤生存率与累积生存率影响因素的单因素分析结果有良好一致性,分化程度、TNM分期、转移灶体积、转移灶数量、转移灶分布、肝切除范围及术前CEA水平同为两者影响因素(P<0.05),而性别、年龄、肿瘤部位、肝功能分级对结直肠癌肝转移患者远期疗效无显著影响(P>0.05)。多因素分析显示分化程度、TNM分期、转移灶数量、术前CEA水平为无瘤生存率及累积生存率的危险因素(OR>1且P<0.05)。结论结直肠癌肝转移患者根治术远期疗效的影响因素较多,无瘤生存率、累积生存率的影响因素不尽相同,而分化程度、TNM分期、转移灶数量、术前CEA水平是两者的共同影响因素,但上述结论仍需更大样本量研究证据支持。
Objective To study the influencing factors of long-term curative effect after radical resection for liver metastasis of colorectal cancer. Methods The clinical data of 68 patients with liver metastasis of colorectal cancer admitted between August 2010 and August 2012, the relationship between clinical data and 3-year survival rates and cumulative survival rate were analyzed retrospectively. The risk factors of tumor free survival rate and cumulative survival rate were analyzed by establishing Cox proportional hazard model. Results There was good consistency between the results of univariate analysis of the factors influencing survival rate and cumulative survival rate.Differentiation degree,TNM stage, volume, number and distribution of metastatic lesions, range of hepatectomy and preoperative CEA level were the influencing factors（P〈0.05） while gender, age, tumor location and liver function grading had no significant effect on long-term outcomes（P〈0.05）. Multivariate analysis showed that differentiation degree, TNM stage, number of metastatic lesions and preoperative CEA level were the risk factors for tumor free survival rate and cumulative survival rate（OR〉1, P〈0.05）. Conclusion There are many influencing factors of long-term curative effect of radical resection for liver metastasis of colorectal cancer. There are certain differences in tumor free survival rate and cumulative survival rate while the differentiation degree, TNM stage, number of metastatic lesions and preoperative CEA level are the common influencing factors of the two. The above conclusion still needs to be supported by a larger number of samples.
出处
《结直肠肛门外科》
2016年第4期369-372,共4页
Journal of Colorectal & Anal Surgery
关键词
结直肠癌肝转移
远期疗效
影响因素
Liver metastasis of colorectal cancer
Long-term curative effect
Influencing factors
