摘要
目的观察英夫利息单抗治疗炎症性肠病(IBD)的疗效及不良反应。方法以2013年5月至2015年2月我院消化内科收治的80例IBD患者为研究对象,随机分为观察组和对照组(各40例),对照组给予常规治疗,观察组在对照组基础上另给予英夫利息单抗治疗,观察治疗后两组临床疗效,比较治疗前后两组C反应蛋白(CRP)、白蛋白(Alb)、血沉(ESR)、血红蛋白(Hb)、结肠切除率、并发症发生率及常见不良反应总体发生率。结果治疗后,观察组总有效率为87.50%,显著高于较对照组(67.50%)(P<0.05);两组CRP、ESR均较治疗前显著降低,Hb、ALB显著升高,且观察组CRP(15.56±3.10)mg/L、ESR(15.26±6.04)mm/h显著低于对照组,Hb(128.00±7.78)g/L、ALb(39.12±8.75)g/L显著高于对照组(P<0.05);观察组结肠切除率为2.50%、常见不良反应总体发生率2.50%,与对照组相比,差异均有统计学意义(x2=6.135,P<0.05;x2=3.914,P<0.05)。结论英夫利昔单抗可显著降低IBD患者CRP、ESR表达水平,并显著升高Hb、ALB表达水平,可有效降低患者结肠切除率,值得推广应用。
Objective To observe the effect of infliximab in treating inflammatory bowel disease（IBD） and its common adverse reactions. Methods Eighty patients with IBD treated in department of gastroenterology of our hospital from May 2013 to February 2015 were randomized into the observation group and the control group, 40 cases in each group. The control group was given conventional treatment while the observation group was treated with infliximab, on the basis of the control group. The clinical efficacy after treatment, related indicators [C reactive protein（CRP）, albumin（ALb）, erythrocyte sedimentation rate（ESR）, hemoglobin（Hb）] before and after treatment, rate of colon excision, incidence of complications and adverse reaction were observed and compared between the two groups. Results After the treatment, the total effective rate of observation group（87.50%） was significantly higher than the control group（67.50%）（P〈0.05）; CRP and ESR were significantly lower than those before treatment while Hb and ALB were significantly higher. CRP [（15.56±3.10） mg/L] and ESR [（15.26±6.04）mm/h] in the observation group were significantly lower than those in the control group while Hb [（128.00±7.78）g/L] and ALB [（39.12±8.75） g/L] were significantly higher（P〈0.05）, The rate of colon excision（2.50%） and incidence of adverse reaction（2.50%） in the observation group after the treatment were significantly higher than the control group（x^2=6.135, P〈0.05; x^2=3.914, P〈0.05）. Conclusion Infliximab can significantly reduce expression levels of CRP and ESR in patients with IBD and significantly improve Hb and ALB. It also can effectively reduce the rate of colon excision.
出处
《结直肠肛门外科》
2016年第4期420-423,共4页
Journal of Colorectal & Anal Surgery
关键词
炎症性肠病
英夫利息单抗
疗效
不良反应
Inflammatory bowel disease
Infliximab
Efficacy
Adverse reaction
