摘要
目的探讨辅助生殖技术结合本院制剂加味六味地黄汤对体外受精-胚胎移植（IVF-ET）妊娠率的影响。方法选择2014年~2015年间在我院行IVF-ET患者104例作为对照组,行IVF-ET同时联合加味六味地黄汤进行治疗的106例为中药组。两组均采用标准长方案垂体降调节治疗。中药组在启动降调之前先予加味六味地黄汤治疗3个月,在经期结束后服用加味六味地黄汤,每日1剂,直至下一次月经来潮时停用,疗程为3个月经周期。疗程结束后行IVF-ET,给予促性腺激素释放激素激动剂（GnRH-a）的同时加用加味六味地黄汤,连续7 d;取卵后予黄体酮的同时也予加味六味地黄汤。对照组不用中药。对两组的临床资料和结局进行分析和判断。结果两组的人绒毛膜促性腺激素（HCG）日促黄体生成素（LH）、孕酮（P）及雌激素（E_2）水平比较,差异无统计学意义（P〉0.05）;而中药组的促性腺激素（Gn）总天数总量更低,HCG日内膜厚度厚于对照组,中药组的移植胚胎数和妊娠率均高于对照组,差异有统计学意义（P〈0.05）。结论在采取辅助生殖技术的同时,运用加味六味地黄汤中药能减少Gn用量和提高妊娠率。
OBJECTIVE METHODS To observe the effects of herbal medicines of Jia Wei Liu Wei Di Huang Tang on the gestation rate of IVF-ET. METHODS The clinical data of 310 IVF-ET cases in the hospital between June 2014 and 2015 were selected, and were divided into IVF-ET plus Herbal Medicine group （n = 106）and control group （n = 104）. Both two groups received routine regimen of IVF-ET. Before the IVF-ET,the herbal group received Jia Wei Liu Wei Di Huang Tang once a day until the next time menstruation for three months. The herbal group received Jia Wei Liu Wei Di Huang Tang from the day of medication of GnRH-a for 7days and was given Jia Wei Liu Wei Di Huang Tang from the day of embryo transfer. Clinical outcomes were compared in the two groups. RESULTS The period of Gn and the difference of serum LH, P, E2 level on the day of administration of HCG were insignificant between the two groups（P〉0.05）. The dosage of Gn, implantation rate and gestation rate in the herabal group was higher than that in the control group（P〈0.05）. CONCLUSION The application of herbal medicines of Jia Wei Liu Wei Di Huang Tang can increase the implantation rate and gestation rate during assisted reproduction.
出处
《今日药学》
CAS
2016年第10期721-723,727,共4页
Pharmacy Today
基金
广东省中医药局科研课题(20142098)
