摘要
目的:探讨莫西沙星或左氧氟沙星联合抗结核药物治疗难治性结核性脑膜炎的疗效及安全性。方法:收取2011年12月至2014年12月我院收治的难治性结核性脑膜炎患者68例作为研究对象,随机分为观察组及对照组各34例,分别采用莫西沙星或左氧氟沙星联合抗结核药物进行治疗。对两组患者临床疗效、脑脊液相关指标、生活质量评分以及不良反应发生情况进行观察与对比。结果:治疗后两组患者脑脊液压力、蛋白质含量及白细胞数量均明显降低,葡萄糖含量明显升高,差异均有统计学意义(P<0.05);观察组变化幅度明显强于对照组(P<0.05)。观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组患者在PF、RP、BP、GH及VT等维度得分均显著高于对照组,差异有统计学意义(P<0.05);两组患者在SF、RE及MH等维度得分无显著差异(P>0.05)。两组患者不良反应发生率无显著差异(P>0.05)。结论:莫西沙星联合抗结核药物治疗难治性结核性脑膜炎疗效优于左氧氟沙星,安全性高,值得临床推广应用。
Objective： To compare the clinical effect and safety of moxifloxacin or levofloxacine combined with antituberculosis drugs in treatment of refractory tuberculous meningitis. Methods： 68 patients with refractory tuberculous meningitis accepted in our hospital fi＇om December 2011 to December 2014 were randomly divided into observation group and control group with 34 cases in each group. The patients in observation group and control group were given moxifloxacin and levofloxacin respectively combined with antituberculosis. The clinical effect, indexes of CSF, life quality and adverse reactions were observed and compared between two groups. Results： The CSF pressure, protein and WBC counts were decreased and the content of glucose was increased after treatment in two groups （P〈0.05）. The changing of observation group was higher than control group （P〈0.05）. The total efficacy of observation group was obviously higher than that of control group with statistical significance （P〈0.05）. The scores in PF, RP, BP, GH and VT of observation group were higher than those of control group （P〈0.05）, but there were no difference in SF, RE and MH between two groups （P〉0.05）. The rate of adverse reactions of two groups had no difference （P〉0.05）. Conehtsions： Moxifloxacin combined with antituberculosis drugs has better effect than levofloxacine in treatment of refractory tuberculous meningitis, which is safe and worth clinical application.
出处
《现代生物医学进展》
CAS
2016年第34期6717-6720,共4页
Progress in Modern Biomedicine
