摘要
目的探讨左乙拉西坦联合家庭式干预治疗儿童癫痫的疗效及安全性分析。方法选择2013年1月—2016年3月收治的癫痫患儿80例,根据治疗方法的不同,分为观察组和对照组,每组40例,2组患儿年龄、病程、发作类型等差异无统计学意义。2组患儿均口服左乙拉西坦,治疗剂量为10 mg/kg,每日分为早晚2次服用,根据临床疗效及耐受性逐渐增加剂量至30 mg/(kg·d)。治疗医师应尽量使用最低的有效剂量控制癫痫发作,观察组在此基础上给予家庭式干预,2组患儿均治疗3个月。比较2组患儿的临床疗效、治疗后的认知功能及生活质量评分,观察并记录不良反应的发生情况。结果治疗后,观察组总有效率为87.50%,高于对照组的70.00%,差异有统计学意义(P<0.05)。观察组患儿治疗后各项生活质量评分均明显优于对照组患儿,差异均有统计学意义(P<0.05)。治疗后,观察组患儿智商、语言智商、操作智商、总智商评分均高于对照组患儿,差异均具有统计学意义(P<0.05)。2组患儿总不良反应发生率相当,差异无统计学意义(P>0.05)。结论左乙拉西坦联合家庭式干预,能显著提高患儿的临床疗效,提高患儿生活质量,提高患儿认知评分,且不良反应较少,因此安全性高,值得临床推广应用。
Objective To evaluate the efficacy and safety of levetiracetam in combination with family intervention in the treatment of epilepsy in children. Methods Eighty cases with epilepsy enrolled in our hospital from January, 2013 to March,2016 were randomly divided into the control group and observation group The age, course of disease and type of seizure had no statistical differences between the two groups. Two groups were treated with levetiracetam which was orally administered at the dose of 10 mg/kg taken twice daily, in the morning and evening. According to clinical efficacy and tolerability the dose was gradually increased to 30 mg/（ kg · d）. Therapist should try to use the lowest effective dose to control seizures. The observation group on this basis was given family-style intervention, and the two groups were treated for 3 months. The clinical efficacy, cognitive function and quality of life scores of the two groups were compared and the incidence of adverse reactions were observed and recorded. Results After the treatment, the total effective rate of the observation group was 87.50% ,higher than the control group 70.00% , with a statistical significance（ P 〈 0.05 ）. The quality of life scores in the observation group were significantly better than those in the control group（P 〈 0. 05）. After the treatment, the IQ, VIQ, PIQ, FIQ scores of the observation group were higher than those of the control group, and the differences were statistically significant（ P 〈 0.05 ）. There was no significant difference in the incidence of adverse reactions between the two groups（ P 〉 0.05 ）. Conclusion Levetiracetarn combined with family intervention can significantly improve the clinical efficacy of children epilepsy, improve the quality of life of children, improve cognitive scores in children, and fewer adverse reactions, thus safer and worthy of clinical application.
出处
《中华全科医学》
2016年第12期2063-2066,共4页
Chinese Journal of General Practice
基金
浙江省金华市科学技术研究计划项目(2011-3-027)
浙江省公益技术应用研究实验动物项目(2015C3715)
2014年浙江省医药卫生一般研究计划项目(2014KYB136)
关键词
左乙拉西坦
家庭式干预
癫痫
临床疗效
生活质量
Levetiracetam
Family intervention
Epilepsy
Clinical efficacy
Quality of life
