摘要
目的探讨生育因素在原发性胆汁性胆管炎(PBC)发病中的作用。方法收集2013年10月-2015年8月就诊于西京医院并明确诊断的273名PBC女性患者。排除合并自身免疫性肝炎、原发性硬化性胆管炎重叠综合征、肝性脑病及经电话回访后资料不全的患者,共纳入有女性亲属配比的54名女性PBC患者(PBC组)加入本次调查研究。同一时间段收集与PBC患者在10岁年龄段内的女性亲属,排除合并其他系统严重疾病及经电话回访资料不全者,共纳入88名参与者(亲属组)。对所有入选者采用PBC女性生育因素调查表进行问卷调查,收集数据。计量资料2组间比较采用独立样本的t检验,计数资料组间比较采用χ2检验,剂量-反应关系采用多因素Logistic回归分析。结果 PBC组平均生育次数显著大于亲属组(2.55±1.84 vs 1.84±0.95;t=2.708,P=0.009)。对2组生育次数进行剂量-反应关系连续变量统计分析提示,生育次数与PBC发病呈剂量-反应关系(P=0.002)。结论生育次数可能是PBC发病的相关因素,通过剂量-反应关系参与PBC发病。对于PBC易感性的女性,减少生育次数可能会降低其发生PBC的概率。
Objective To investigate the role of productive factors in the development of primary biliary cholangitis（ PBC）. Methods A total of 273 female patients with a definite diagnosis of PBC who visited Xijing Hospital from October 2013 to August 2015 were enrolled. The patients with autoimmune hepatitis,primary sclerosing cholangitis overlap syndrome,and hepatic encephalopathy and those with incomplete data after telephone follow- up were excluded,and 54 female PBC patients who had female relatives were finally enrolled（ PBC group）.The female relatives who were less than 10 years older or younger than the patients were collected,and those with severe systemic diseases and incomplete data after telephone follow- up were excluded; finally 88 relatives were enrolled（ relative group）. The questionnaire for female reproductive factors in PBC was used to survey all these enrolled patients and collect data. The t- test was used for comparison of continuous data between groups,the chi- square test was used for comparison of categorical data between groups,and a multivariate logistic regression analysis was used for the analysis of dose- response relationship. Results The PBC group had a significantly higher number of births than the relative group（ 2. 55 ± 1. 84 vs 1. 84 ± 0. 95,t = 2. 708,P = 0. 009）. Furthermore,there was a significant dose- response pattern between the number of births and the development of PBC（ P = 0. 002）. Conclusion The number of births may be associated with the development of PBC in a dose- response manner. As for the female population susceptible to PBC,a reduction in the number of births may reduce the possibility of PBC.
出处
《临床肝胆病杂志》
CAS
2016年第11期2130-2133,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(81070326
81370519
81200290)
陕西省科技统筹创新工程计划(2011KTCL03-09)
关键词
肝硬化
胆汁性
生育史
危险因素
liver cirrhosis
biliary
reproductive history
risk factors
