摘要
目的探讨间质性肺疾病(ILD)患儿支气管肺泡灌洗液(BALF)中铁蛋白水平的变化及临床意义。方法选取2008年8月至2015年2月随州市妇幼保健院收治的ILD患儿24例,其中过敏性肺炎(HP)9例(HP组),特发性间质性肺炎(IIP)11例(IIP组),特发性肺含铁血黄素沉着症(IPH)4例(IPH组);并选取30例非ILD患儿作为对照组;各组患儿均行左肺舌叶或右肺中叶灌洗,检测患儿BALF中免疫细胞数量及铁蛋白水平。结果 HP组、IIP组和IPH组患儿BALF中细胞总数、巨噬细胞、淋巴细胞及中性粒细胞数均显著高于对照组(P<0.05)。HP组、IIP组和IPH组患儿BALF中细胞总数比较差异无统计学意义(P>0.05);HP组、IIP组和IPH组患儿BALF中巨噬细胞及中性粒细胞数比较差异均有统计学意义(P<0.05),HP组患儿BALF中淋巴细胞数显著高于IIP组和IPH组(P<0.05),IIP组与IPH组患儿BALF中淋巴细胞数比较差异无统计学意义(P>0.05)。HP组、IIP组、IPH组和对照组患儿BALF中铁蛋白水平分别为(0.2±0.1)、(0.9±0.3)、(10.0±1.9)、(0.3±0.1)g·L-1,IIP组和IPH组患儿BALF中铁蛋白水平显著高于对照组和HP组(P<0.05),IPH组患儿BALF中铁蛋白水平显著高于IIP组(P<0.05),但HP组患儿BALF中铁蛋白水平与对照组比较差异无统计学意义(P>0.05)。结论 ILD患儿BALF中铁蛋白水平升高;BALF中铁蛋白可作为儿童ILD(尤其是IPH)的辅助检测指标。
Objective To investigate the clinical significance of the ferritin expression in bronchoalveolar lavage fluid （BALF） of patients with interstitial lung disease （ILD）. Methods A total of 24 ILD children selected in Suizhou Maternal and Child Health Hospital from August 2008 to February 2015 ,were divided into hypersensitivity pneumonitis（HP） group（n = 9）, interstitial pneumonia （IIP） group （ n = 11 ） and idiopathic pulmonary hemosiderosis （IPH） group （ n = 4）. In addition, 30 cases of non ILD children were selected as control group. The children in the groups were performed with bronchoalveolar lav- age through lingula of left lung or middle lobe of right lung. The number of immune cells and ferritin level in BALF were detec- ted in the groups. Results The total number of cells, macrophages, lymphocytes and neutrophils in BALF of HP group, IIP group and IPH group was significantly higher than that of control group （ P 〈 0. 05 ）. There was no significant difference in the total number of cells in BALF of HP group, IIP group and IPH group （ P 〉0. 05 ）. There were significant differences in the number of macrophages and neutrophils in BALF among HP group, IIP group and IPH group （P 〈 0.05 ）. The number of lym- phocytes in BALF of HP group was significantly higher than that of IIP group and IPH group （ P 〈 0.05 ）. There was no signifi- cant difference in the number of lymphocytes in BALF between IIP group and IPFI group（P 〉 0.05 ）. The level of ferritin in BALF of liP group, IIP group, IPH group and control group was （0. 2 ±0. 1 ）, （0.9 ± 0. 3 ）, （ 10. 0 ± 1.9） and （0. 3 ± 0. 1 ） g · L- 1 respectively; the level of ferritin in BALF of liP group and IPH group was significantly higher than that of control group and HP group （P 〈 0.05 ） ; the level of ferritin in BALF of IPH group was significantly higher than that of group IIP （ P 〈 0.05 ） ; but there was no significant difference in the level of ferritin in BALF between HP group and control group （ P 〉 0.05）. Conclusion The level of ferritin in BALF is increased in children with ILD. Ferritin in BALF can be used as an auxil- iary detection index of ILD children, especially in IPH children.
出处
《新乡医学院学报》
CAS
2016年第11期990-992,共3页
Journal of Xinxiang Medical University
关键词
支气管肺泡灌洗液
铁蛋白
间质性肺疾病
儿童
bronchoalveolar lavage fluid
ferritin
interstitial lung diseases
chlidren
