摘要
目的:观察独活寄生汤联合甲氨蝶呤、柳氮磺吡啶治疗强直性脊柱炎的临床疗效。方法:将87例强直性脊柱炎患者随机分成对照组45例和治疗组42例。对照组予甲氨蝶呤片联合柳氮磺吡啶片治疗,治疗组在对照组西药治疗基础上加用独活寄生汤加减治疗。结果:治疗3个月后,总有效率治疗组为85.71%,对照组为46.67%,组间比较,差异有统计学意义(P<0.05);两组中医证候积分、BASDAI、BASFI、脊柱痛(VAS评分)、指地距及实验室指标hs-CRP、ESR治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:独活寄生汤联合甲氨蝶呤、柳氮磺吡啶治疗强直性脊柱炎疗效确切。
Objective： To investigate the clinical effect of Duhuo Jisheng decoction combined with methotrexate and salicylazosulfapyridine in the treatment of ankylosing spondylitis. Methods： A total of 87 patients with ankylosing spondylitis were randomly divided into control group with 45 patients and treatment group with 42 patients. The patients in the control group were given methotrexate tablets combined with salicylazosulfapyridine tablets,and those in the treatment group were given Duhuo Jisheng decoction in addition to the Western medicine treatment for the control group. Results： After three months of treatment,the treatment group had a significantly higher overall response rate than the control group（ 85. 71% vs 46. 67%,P 〈0. 05）. After treatment,TCM syndrome score,Bath Ankylosing Spondylitis Disease Activity Index,Bath Ankylosing Spondylitis Functional Index,Visual Analogue Scale score for spondylalgia,finger to floor distance,high-sensitivity C-reactive protein,and erythrocyte sedimentation rate were significantly improved in each group and showed significant differences between the two groups（ P 〈0. 05）. Conclusion：Duhuo Jisheng decoction combined with methotrexate and salicylazosulfapyridine has a goo d clinical effect in the treatment of ankylosing spondylitis.
作者
杨吉勇
YANG Ji - yong(Hanjiang Hospital of Hanjiang Water Conservancy and Hydropower（Group） Co. , Ltd. , Shiyan 442700, Hubei, Chin)
出处
《湖南中医杂志》
2016年第11期15-17,24,共4页
Hunan Journal of Traditional Chinese Medicine
关键词
强直性脊柱炎
中西医结合疗法
独活寄生汤
甲氨蝶呤
柳氮磺吡啶
ankylosing spondylitis
integrated traditional Chinese and Western medicine therapy
Duhuo Jisheng decoction
methotrexate
salicylazosulfapyridine
