摘要
目的:探讨大剂量甲氨蝶呤化疗方案治疗儿童急性淋巴细胞白血病导致血药浓度异常升高的影响因素,为临床合理使用提供帮助。方法:通过医院电子病历系统,查阅患者各项诊疗、检查及用药资料,根据相关指南和诊疗规范对1例大剂量甲氨蝶呤治疗儿童急性淋巴细胞白血病血药浓度异常升高的用药情况进行分析。结果:该患者甲氨蝶呤血药浓度超过正常值10天,可能与化疗方案的选择、亚叶酸钙的解救、水化碱化、合并用药等因素相关。结论:临床医生应关注影响甲氨蝶呤血药浓度的多种因素,提高疗效,减少不良反应的发生;临床药师有必要参与患者治疗。
Objective： To explore the influencing factors for abnormally high blood concentratio I in high-dose methotrexate chemotherapy tbr children with acute lymphoblastic leukemia to provide help for clinical rational drug use. Methods： Through the hospital electronic medical records system, the diagnosis, treatment, examinations and medication information of one child with acute lympho-blastic leukemia treated with higb-dose methotrexate and complicated with abnormally high blood co lcentration were reviewed, and according to the relevant guidelines and diagnosis norms, the medication of the patient was analyzed. Results： The patient＇s methotrexate plasma concentration exceeded the normal value for more than 10 days, which was related with the choice of chemotherapy, leucovorin rescue, hydration and alkalization, drug combination and so on. Conclusion： Clinicians should pay attention to the influencing thctors for methotrexate blood concentration in order to enhance the effectiveness and reduce the il cidence of adverse reactions, and clinical pharmacists should participate in the treatment of the patients.
出处
《中国药师》
CAS
2016年第12期2326-2328,2332,共4页
China Pharmacist
关键词
甲氨蝶呤
儿童急性淋巴细胞白血病
血药浓度
用药分析
Methotrexate
Chihlren with acute lymphoblastic leukemia
Blood drug concentration
Medication analysis
