摘要
敏感性皮肤是指皮肤对多种内外因素的耐受性降低、敏感性增强。敏感皮肤的发生与年龄、性别、身体解剖部位以及种族有关。敏感性皮肤者生活质量下降。由于其病因不明，有效控制敏感性皮肤一直是个挑战。近来研究显示，表皮通透屏障功能和瞬时感受器电位香草酸受体与敏感性皮肤的发生有关。因此，改善表皮通透屏障功能和瞬时感受器电位香草酸受体抑制剂可能有助于改善敏感性皮肤。
Sensitive skin is a skin condition featured by high sensitivity and low tolerance in response to external and internal stimuli. The prevalence of sensitive skin varies with age, gender, body sites, as well as race. The quality of life is substantially reduced in subjects with sensitive skin. Due to uncertainty of etiology, it has been a challenge to effectively manage sensitive skin. Recent studies have demonstrated pathogenic roles of epidermal permeability barrier and transient receptor potential vanilloid 1 （TRPV1） in the development of sensitive skin. Therefore, improvement in epidermal permeability barrier function and utilization of TRPV1 inhibitors may be valuable approaches to the management of sensitive skin.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2016年第12期899-902,共4页
Chinese Journal of Dermatology
基金
韩国卫生福利部健康技术研发项目（HN11C0048）
关键词
皮肤
表皮
敏感性皮肤
表皮通透屏障功能
透皮水分丢失
Skin
Epidermis
Sensitive skin
Epidermal permeability barrier
Transepidermal water loss
