摘要
EDS1(enhanced disease susceptibility 1)是一种重要的防卫基因,其编码的信号蛋白质位于植物免疫信号网络的关键节点。EDS1的互作蛋白质包括PAD4(phytoalexin defi ciency 4)和SAG101(senescence-associated gene 101)。EDS1在以TIR-NB-LRR(toll-interleukin-1 receptornucleotide binding-leucine-rich repeat)类R蛋白(resistance proteins)为主介导的ETI(effectors-triggered immunity)及不涉及R蛋白的PTI(PAMP-triggered immunity)中均发挥重要作用,主要调控细胞内氧爆发和水杨酸(salicylic,SA)的积累并抑制JA/ET(jasmonic acid/ethylene)通路。该文就EDS1蛋白质的结构特点及其在植物防卫病菌入侵的信号通路中的功能作一综述。
EDSI (enhanced disease susceptibility 1) is an important defense gene which codes a signal protein. The protein locates in the key node of plant innate immune signal network. PAD4 (phytoalexin deficiency 4) and SAG 101 (senescence-associated gene 101) are signaling partners of EDS 1. EDS 1 plays important roles in ETI (effectors-triggered immunity) which is mainly mediated by TIR-NB-LRR (toll-interleukin-1 receptor-nucleotide binding-leucine-rich repeat) resistance proteins and PTI (PAMP-triggered immunity) which is not mediated by any R proteins (resistance proteins). EDS1 primarily regulates intracellular ROS (reactive oxygen species) burst and SA (salicylic) accumulation as well as suppresses JA/ET (jasmonic acid/ethylene) signal pathway. This paper reviews the structure of EDS 1 protein as well as its important roles in defense signal pathways.
出处
《中国细胞生物学学报》
CAS
CSCD
2016年第11期1398-1404,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:30671244、31171472)
高等学校博士学科点专项科研基金(优先发展领域)(批准号:20111302130001)
河北省应用基础研究计划重点基础研究项目(批准号:12967149D)
河北省留学人员科技活动项目择优资助(批准号:2120316)
河北农业大学青年学术带头人项目资助的课题~~