摘要
目的分析南京地区近5年核苷(酸)类药物(NAs)临床应用情况及用药趋势以便合理使用NAs抗病毒。方法对该地区2010-2014年NAs的销售金额,用药频度(DDDs)、日均费用(DDC)及市场构成等指标进行分析。结果该地区NAs的销售金额基本呈逐年上升趋势,2012年增加新品种替诺福韦酯,其中以阿德福韦酯和恩替卡韦使用居多。结论 NAs是慢性乙型肝炎抗病毒治疗的主要手段,应进一步优化治疗方案,降低耐药变异率。
OBJECTIVE To analyze the utilization situation and developing trend of nucleotide antiviral drugs（NAs）in Nanjing area during recent five years,so as to rational use of them.METHODS The sales amount,DDDs,DDC and constituent ratio of manufacturer of NAs were analyzed in the region during 2010 to 2014.RESULTS The sales amount of the NAs increased mainly year by year,and tenofovir was added in 2012.Adefovir dipivoxil and entecavir were commonly used in the majority.CONCLUSION NAs are the main anti-chronic hepatitis B therapy.We should optimize the treatment plan further to reduce the drug resistance rate.
作者
吴丹娜
王敏
韩方璇
邓立新
徐萍
WU Dan-na WANG Min HAN Fang-xuan DENG Li-xin XU Ping(Hainan General Hospital, Haikou, Hainan 570311, China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第23期5364-5366,5370,共4页
Chinese Journal of Nosocomiology
基金
海南省中药现代化专项基金(2015ZY01)
