摘要
目的探讨丙酸氟替卡松联合枸地氯雷他定治疗对变应性鼻炎患者血清嗜酸粒细胞(EOS)、集落刺激因子(CSF)、白介素(IL)-5水平的影响。方法选取136例变应性鼻炎患者作为研究对象,随机分为观察组和对照组。观察组给予丙酸氟替卡松鼻喷雾剂喷鼻,枸地氯雷他定片口服,对照组给予枸地氯雷他定片口服,治疗时间为4周。治疗结束后,采用视觉模拟量表(VAS)对两组患者治疗前后的鼻部症状进行评分,并进行疗效评价。对比两组患者治疗前后血清EOS、CSF和IL-5水平的变化,并分析三者之间的相关性。结果观察组经丙酸氟替卡松和枸地氯雷他定片治疗后,总有效率为94.1%,显著高于对照组的77.9%(P<0.05)。两组患者经治疗后,血清EOS、CSF和IL-5水平与治疗前相比均显著降低,观察组的EOS、CSF和IL-5水平显著低于对照组(P<0.05)。相关性分析结果显示,EOS、CSF和IL-5之间均具有正相关关系(P<0.01)。结论丙酸氟替卡松联合枸地氯雷他定治疗变应性鼻炎患者,能显著降低其血清EOS、CSF和IL-5水平,且CSF和IL-5水平的变化与EOS的变化存在显著正相关。
Objective To study the influence of fluticasone propionate and desloratadine citrate disodium on the level of EOS,CSF,IL-5 in the serum of allergic rhinitis patients.Methods One hundred and thirty-six cases of allergic rhinitis were randomly divided into observation group and control group.The observation group was given oral nasal spray and fluticasone propionate nasal spray,desloratadine citrate disodium tablets orally.The control group was given desloratadine citrate disodium tablets.The time of treatment was 4 weeks.After the treatment,the visual analogue scale（VAS） of nasal symptoms of the patients in two groups were decided.The changes of serum EOS,CSF and IL-5 levels were compared between the two groups before and after treatment,and the correlation between the three groups was analyzed.Results The total effective rate of the observation group with fluticasone propionate and desloratadine citrate disodium after treatment was 94.1 %,significantly higher than that of the control group（77.9 %）.The serum EOS,CSF and IL-5 levels of two groups of patients after treatment were significantly lower than those before treatment.The EOS,CSF and IL-5 levels of observation group were significantly lower than those in the control group（P〈0.05）.The correlation analysis showed that CSF and IL-5 had a positive correlation with EOS（P〈0.01）.Conclusion Fluticasone propionate and desloratadine citrate disodium for the treatment of allergic rhinitis patients can significantly reduce the serum levels of EOS,CSF and IL-5 levels.The CSF,IL-5 and EOS levels are closely related.
出处
《临床和实验医学杂志》
2016年第24期2405-2408,共4页
Journal of Clinical and Experimental Medicine
基金
上海市嘉定区卫生和计划生育委员会科研课题(2015-KY-07)
