摘要
目的:探索中药古方治疗肝癌的用药规律。方法:以"肝癌"、"肝积"、"臌胀"、"黄疸"、"胁痛"为病种关键词进行检索,共收集中药方剂1806首,涉及中药792味,21功效类,利用SPSS22.0软件进行主成分分析。结果:21类中药按照贡献度由高到低排序可分为三部分,常用中药A类(贡献度综合得分为0.1345~0.0892),包含利水渗湿药、清热药、祛风湿药、理气药,其相应的代表药物为茯苓、黄连、独活、木香;较常用中药B类(贡献度综合得分为0.0870~0.0414),包含拔毒生肌药、驱虫药、安神药、收涩药、活血化瘀药、攻毒杀虫止痒药、开窍药、化湿药、平肝息风药、止血药、补虚药;不常用中药C类(贡献度综合得分为0.0384^-0.0439),包含泻下药、涌吐药、化痰止咳平喘药、温里药、消食药。结论:主成分分析可以对中药古方中的中药在治疗肝癌中的贡献度进行排序,其结果具有临床参考价值。
Objective To explore the law governing ancient prescriptions of chinese herbal medicine in pri- mary liver cancer. Methods Data were retrieved by using ＂liver cancer＂, ＂Ganji＂, ＂distention＂, ＂jaundice＂, and ＂hypochondriac＂ as key words. A total of 1806 prescriptions, 792 kinds of herbs and 21 classes were collect- ed. Principal component analysis was performed by using the software of SPSS 22.0 version. Results Accord- ing to the contribution degree from high to low, 21 categories of chinese herbs to treat primary liver cancer were divided into three parts. The commonly used herbs were in part A, in which the composite scores of contribution were 0.1345~0.0892. They were water promoting and diluting drugs, antipyretic, antirheumatics and promoting Qi drugs, and their representatives were Poria cocos, Coptis chinensis, Radix angelicae pubescentis and Costus- toot, respectively. The less commonly used herbs were in part B, in which the eomposite scores of contribution were 0.0870~0.0414. They were Sida myogenic drugs, anthelmintic, sedatives, astringent medicine, blood circula- tion promoting drugs, antipruritic attack toxic pesticides, resuscitation medicine, medicine dampness, Pinggan wind medicine, hemostatics and Tonies. The uncommonly used herbs were in part C, in which composite scores of contribution were 0.0384-0.0439. They were prescription diarrhea, Chung spit medicine, sputum dissolving and anticoughing medicine, warming body drugs and Arodigestive medicine. Conclusion The contribution de- gree of the herbs in treating the primary liver cancer in ancient prescriptions can be sorted by principal compo- nent analysis. The results can be of reference value clinically.
出处
《中国中西医结合外科杂志》
CAS
2016年第6期523-528,共6页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
天津市科技计划项目(2015069)
关键词
中药
主成分分析
肝癌
Chinese herbal medicine
principal component analysis
primary liver cancer
