摘要
目的研究前列地尔联合羟苯磺酸钙对CHD合并CRI患者行PCI时对CIN的预防作用。方法选取需PCI治疗CHD合并CRI患者40例,分为对照组20例(水化疗法)和试验组20例(前列地尔+羟苯磺酸钙+水化疗法)。于PCI前后测定SCr、BUN及GFR,并比较两组CIN发生率。结果术后24 h,试验组SCr及GFR优于对照组(P<0.05);术后48 h,试验组SCr、BUN及GFR优于对照组。试验组CIN发病率与对照组比较,差异无统计学意义(P>0.05)。结论 CHD合并CRI患者行PCI时,使用前列地尔联合羟苯磺酸钙可明显改善患者术后肾功能。
Objective To study the effects of alprostadil combined with calcium dobesilate on the prevention of CIN in the patients with CHD complicated with CRI during PCI. Methods Forty patients with CHD complicated with CRI in need of PCI were enrolled in this study. They were divided into the control group of 20 patients （hydration therapy） and the experiment group of 20 patients （ALP＋calcium sulphate ＋ hydration therapy）. SCr, BUN and GFR were measured before and after PCI, and the incidence of CIN was compared between the two groups. Results The SCr and GFR in the experiment group were better than those in the control group 24 h after operation（P〈0.05）; the levels of SCr, BUN and GFR in the experiment group were superior to those in the control group at 48 h after operation. The incidence rate of CIN was decreased in the experiment group, but there was no statistical significance（P〉0.05）. Conclusion The use of alprostadil combined with calcium dobesilate can significantly improve postoperative renal function in the patients with CHD complicated with CRI during PCI.
出处
《中国现代医生》
2016年第30期84-86,共3页
China Modern Doctor
关键词
前列地尔
羟苯磺酸钙
对比剂肾病
慢性肾功能不全
Alprostadil
Calcium dobesilate
Contrast-induced nephropathy
Chronic renal insufficiency
