摘要
目的探讨低温机械灌注（HMP）保存老年公民逝世后器官捐献（DCD）供者供肾的临床应用效果。方法回顾性分析47例老年DCD供者供肾移植的临床资料，根据供肾保存方式的不同，分为低温机械灌注组（HMP组，32例）和静态冷保存组（CS组，15例），对两组受者术后1年内移植肾功能恢复延迟（DGF）发生率，血肌酐，以及移植肾存活率等资料进行比较。结果HMP组受者平均住院时间比CS组缩短了16．6d（P=0．37）。术后1年时，HMP组平均血肌酐值为125．8μmol／L，低于CS组的198．6μmol／L（P=0．42）；术后1年时，HMP组移植肾存活率为96．9％（31／32），高于CS组的80％（12／15）（P=0．057）。HMP组术后D（沛发生率为6．3％（2／32），低于CS组的13．2％（2／15）（P=0．24）。结论低温机械灌注保存可以客观评价老年DCD供者供肾功能，并且能够改善供肾质量。
Objective To explore clinical application efficacy of Lifeport machine perfusion in improving the quality of elderly donor kidneys from donation after citizens death （DCD）. Methods The clinical data of 47 DCD kidney donors more than 60 years old in our center from January 2013- December 2015 were retrospectively analyzed. The donors were divided into hypothermic mechanical perfusion group （HMP） group （n = 32） and static cold preservation group （SC） （n = 15） accordance with kidney preservation methods. The incidence of postoperative one-year delayed graft function （DGF）, blood creatinine and the survival rate of the renal grafts were compared between two groups. Results The incidence of DGF in HMP group （6. 3 %） was decreased as compared with SC group （13.2%） （P〈0. 24）. The average length of hospital stay in HMP group was 16. 6 days, shorter than in SC group （P = 0. 37）. One year after renal transplantation, the average blood creatinine level in HMP group was lower than in SC group （125. 8μmol/L vs. 198. 6 μmol/L, P = 0. 42）. The 1-year graft survival rate in HMP group was higher than in SC group （96. 9% vs. 80%, P = 0. 057）. Conclusion Lifeport machine perfusion preservation can objectively evaluate the renal function of elder DCD donors and improve quality of donor kidneys.
出处
《中华器官移植杂志》
CAS
CSCD
2016年第8期468-471,共4页
Chinese Journal of Organ Transplantation
基金
国家自然基金青年基金（81500574）
公益性行业科研专项（201302009）
天津市卫生局课题（2014KZ027）
关键词
肾移植
供者
老年
肾脏
机械灌注
Kidney transplantation
Donor
Elderly
Kidney
Machine perfusion
