摘要
目的调查社区人群的糖代谢及胰岛功能状况。方法对社区健康体检人群789例进行流行病学问卷调查及体格检查,收集相关代谢指标,行75g口服葡萄糖耐量试验,测定糖负荷前后血清胰岛素水平。结果新诊断糖尿病人群161例(20.4%)(NDM组),糖尿病前期人群336例(42.6%)(PDM组)。NDM组BMI、TG、血清尿酸、空腹血糖、HbA1c水平均高于PDM组和正常糖耐量人群组(NGT组)(P<0.05)。NDM组和PDM组胰岛素释放指数、胰岛素敏感性指数低于NGT组,且PDM组上述指标高于NDM组(P<0.05)。NDM组和PDM组HOMA-IR高于NGT组,且NDM组高于PDM组(P<0.05)。结论社区体检人群中新诊断糖尿病及糖尿病前期人群的发病率较高,在糖尿病前期人群中已出现代谢紊乱及胰岛功能受损。
Objective To investigate the glucose metabolism status and islet function in a community population .Methods The epidemiological questionnaire and general physical examination were performed in 789 people in community health examination .The clinical data were collected and 75 g oral glucose tolerance test was performed for measuring levels of serum insulin before and after glycemic load .Results In this community population ,the incidences of newly-diagnosed diabete mellitus（NDM） and pre-diabetes mellitus（PDM） were 20.4% and 42.6% ,respectively .The levels of body mass index ,triglyceride ,serum uric acid ,fasting blood glucose and HbA1c in group NDM were higher than those in groups of PDM and NGT （normal glucose tolerance）（P〈0 .05） .Insulin release index（InsR30 ,InsR120） and Matsuda ISI in groups of NDM and PDM were lower than those in group NGT ,which in group PDM were high than those in group NDM （P〈0 .05） .In contrast ,HOMA-IR in groups of NDM and PDM was higher than that in group NGT ,which in group NDM was higher than that in group PDM （P〈0 .05） .Conclusion The incidences of NDM and PDM are higher in the community population .The metabolic disorders and the decline of islet function have already appeared in PDM patients .
出处
《江苏医药》
CAS
2016年第23期2546-2549,共4页
Jiangsu Medical Journal
基金
江阴市卫生局科研立项项目(Z201401)
关键词
糖尿病
糖耐量异常
胰岛功能
Diabetes mellitus
Glucose tolerance abnormality
Islet function
