摘要
目的探讨辅酶Q10联合参麦注射液对胎粪致新生儿窒息后脑缺氧性损伤后血清酶的影响。方法选取天津医科大学静海临床学院胎粪致新生儿窒息后脑缺氧性损伤患儿64例,随机分为2组,各32例,对照组予以维持充足的通换气及循环功能及常规药物治疗;研究组在常规治疗基础上予以辅酶Q10联合参麦注射液治疗,共治疗7d为一疗程,测定血清酶、心肌损伤标志物、氧化应激及炎症相关因子等指标,同时对比临床疗效及并发症。结果与治疗前比较,2组治疗后肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)、天门冬氨酸氨基转移酶(aspartic transaminase,AST)、乳酸脱氢酶(lactate dehydrogenase,LDH)、肌酸激酶(creatine kinase,CK)及α-羟丁酸脱氢酶(αhydroxybutyric dehydrogenase,α-HBDH)含量降低,心肌营养因子-1(myocardial nutritional factor-1,CT-1)、心肌肌钙蛋白I(cardiac troponin I,CTn I)及肌红蛋白(myoglobin,Mb)含量降低,超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malonaldehyde,MDA)含量降低,谷胱甘肽过氧化酶(glutathion peroxidase,GSH-Px)含量升高,脂联素(adiponectin,APN)、胰岛素样生长因子-1(insulin-like growth factor,IGF-1)含量升高,瘦素(leptin)含量降低(P<0.05);与对照组比较,研究组治疗后CK-MB、AST、LDH、CK及α-HBDH含量较低,CT-1、CTn I及Mb含量较低,SOD、MDA含量较低,GSH-Px含量较高,APN、IGF-1含量较高,Leptin含量较低(P<0.05);在临床疗效上,对照组总有效率65.63%与研究组总有效率87.50%对比,差异有统计学意义(P<0.05)。结论辅酶Q10联合参麦注射液对胎粪致新生儿窒息后脑缺氧性损伤疗效确切,降低血清酶及心肌损伤,安全性高。
Objective To investigate the effect of coenzyme Q10 combined with Shenmai injection on serum enzyme in the treatment of brain hypoxic injury after asphyxia by meconium in newborn. Methods 64 cases with brain hypoxic injury after asphyxia by meconium from Medical University of Tianjin Jinghai Clinical College were selected and randomly divided into 2 groups,32 cases in each group. The control group received maintained ventilation and circulation function and routine drug therapy adequate,and the experiment group received more with coenzyme Q10 combined with Shenmai injection for 7 days. Serum enzymes and myocardial injury markers,oxidative stress and inflammation related factors and the clinical effect and complications were compared after the treatment. Results Compared with before treatment,levels of CK-MB,AST,LDH,CK and α-HBDH decreased in two groups after the treatment,levels of CT-1,CTn I and Mb decreased,levels of SOD and MDA decreased,contents of GSH-Px,APN,IGF-1increased,contents of Leptin decreased（ P〈0. 05）. Compared with the control group,the levels of CK-MB,AST,LDH,CK and α-HBDH in the experiment group were lower,levels of CT-1,CTn I and Mb were lower,levels of SOD and MDA were lower,contents of GSH-Px,APN,IGF-1 were higher,contents of Leptin were lower（ P〈0. 05）. The clinical curative effect rate of control group（ 65. 63%） was lower than the experiment group（ 87. 50%）（ P〈0. 05）. Conclusion Coenzyme Q10 combined with Shenmai injection in the treatment of brain hypoxic injury after asphyxia by meconium in newborn is curative effective with high safety,and it can reduce serum enzyme and myocardial injury.
出处
《中国生化药物杂志》
CAS
2016年第11期179-182,共4页
Chinese Journal of Biochemical Pharmaceutics
