摘要
以廉价的对羟基苯甲酸为起始原料,经酯化、卤代、氨解、硫代、Hantzsch反应、Duff反应、醚化、水解等十步反应,成功地合成目标化合物非布索坦,总收率为10.87%。目标化合物结构经质谱、红外、氢谱和碳谱得到确证。研究结果表明:实验所采用的合成路线毒性小、成本低、操作简单,为工业化生产开辟了一条新的路线。
The target compound Febuxostat was synthesized from the cheap material p-hydroxylbenzoic acid by a ten-step reaction,including esterification,halogeno,ammonolysis,thio,Hantzsch reaction,Duff reaction,etherification,and hydrolysis. The total yield was 10. 87%. The structure of Febuxostat was confirmed by IR,MS,1H-NMR and13C-NMR. The research results indicated that the toxicity and the cost of this synthetic route were reduced,the operation was simple. This method was suitable for industrial manufacture.
出处
《广西大学学报（自然科学版）》
CAS
北大核心
2016年第6期2044-2048,共5页
Journal of Guangxi University（Natural Science Edition）
基金
国家自然科学基金资助项目(51203091)
辽宁省教育厅科学研究一般项目(L2015383)
沈阳工业大学博士启动基金资助项目(521422)
