摘要
目的旨在加强对小儿EB病毒(EBV)感染特点的认识,以便早期诊断和针对性的有效治疗。方法选择2009年7月-2015年10月120例EB病毒感染患儿血浆EBV-DNA或VCA-IgM抗体阳性,结合其临床表现、实验室检查,按诊断分为IM组43例和普通EB病毒感染组77例,比较两组患儿特点,数据采用SPSS 13.0软件进行统计分析。结果 120例患儿以传染性单核细胞增多症为主,共43例占35.8%;发热、扁桃体红肿及渗出物和淋巴结肿大三联征是IM典型临床表现,眼睑水肿、肝脾肿大的发生率显著高于EBV感染组(P<0.05);IM组中并发噬血细胞综合征和转为慢性活动性EB病毒感染各1例,余均临床治愈,普通EBV感染组77例均治愈,无1例严重合并症发生,无1例死亡。结论 Real-time PCR法检测血浆EBV-DNA有助于EBV感染患儿的早期诊断;传染性单核细胞增多症并非该病毒感染所致的唯一疾病,混合感染多见,异型淋巴细胞比例>10%诊断意义下降,加用丙种球蛋白等治疗措施可取得较好效果。
OBJECTIVE To study the specialty of Epstein Barr virus（EBV）infection so as to guide early diagnosis and effective treatment.METHODS A total of 120 children with EBV infection from Jul.2009 to Oct.2015 were selected,who was positive for EBV-DNA or VCA-IgM antibody were analyzed.Considering the clinical manifestation and laboratory inspection,the children divided into IM group with 43 cases and simple EBV infection group with 77 cases,and characters of these children in these two groups were compared.SPSS 13.0was used for data analysis.RESULTS Among the 120 children,infectious mononucleosis（IM）was the main disease with 43 cases accounting for 35.8%.Fever,tonsil inflammation and diffusate,and lymphadenectasis were the three main clinical manifestations of IM.The incidences of palpebral oedema and hepatosplenomegaly in IM group were sisnificeatly higher than the EBV infection group（P0.05）.There were one case of concurrency hepatosplenomegaly and one cases of active chronic EBV infection in IM group,and the rest got cured in clinic.There was no concurrency or death in EBV infection group,all 77 cases cured.CONCLUSION Real-time PCR test for EBV-DNA in plasma is good for early diagnosis for EBV infection children.IM is not only one of disease in children with EBV infection,and is likely to see mixed infection.The diagnostic significance of abnormal lymphocyte10%is declining.It will have better effect to add gamma globulin into treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第24期5707-5709,共3页
Chinese Journal of Nosocomiology
基金
广东省医学科研基金资助项目(A2009500)
关键词
EB病毒
小儿
感染
诊断
治疗
Epstein-Barr virus
Children
Infection
Diagnosis
Trea-tment
