摘要
目的:研究健脾化湿祛瘀解毒法治疗Ⅲ-Ⅳ期结肠腺癌的临床疗效及对患者生存期的影响。方法:选取60例Ⅲ-Ⅳ期结肠腺癌患者,随机分为对照组与观察组,每组各30例,对照组行单纯化疗,观察组在化疗的基础上联合自拟健脾化湿祛瘀解毒方剂治疗,比较两组患者的临床疗效、生存期及不良反应等发生情况。结果:观察组肿瘤稳定率为90.00%,对照组肿瘤稳定率为76.67%,两组比较,差异有统计学意义(P<0.05);治疗后观察组卡氏评分改善幅度及提高率均明显高于对照组(P<0.05);治疗后观察组中医证候评分明显低于对照组,有效率为90.00%,明显高于对照组的73.33%(P<0.05);观察组患者的2年及3年生存率均明显高于对照组,且观察组的无进展生存期较对照组明显延长(P<0.05);观察组的肝肾毒性、骨髓抑制、胃肠道反应发生率均明显低于对照组(P<0.05)。结论:采用健脾化湿祛瘀解毒法治疗Ⅲ-Ⅳ期结肠腺癌能够改善患者免疫功能、延长无进展生存期、提高生存率并降低化疗不良反应。
Objective： To inveterate the effects of Jianpi Huashi Quyu Jiedu method treatment of stage Ⅲ- Ⅳcolon adenocarcinoma and the survival of patients. Methods： 60 cases of patients with stage Ⅲ- Ⅳcolon adenocarcinoma were randomly divided into two groups： 30 patients were given chemotherapy alone（ the control group）,30 cases were given chemotherapy and Jianpi Huashi Quyu Jiedu treatment,and the clinical prognosis and survival of the two groups were compared. Results： The tumor stable rate was90. 00% in the observation group,statistically higher than 76. 67% in the control group（ P〈0. 05）; after treatment,the KPS score improved margin and the its improvement rate in observation group was significantly higher than that in the control group（ P〈0. 05）; after treatment,the syndromes score in observation group was significantly lower than that in the control group（ P〈0. 05）,and the syndromes total effective rate was 90. 00%,higher than 73. 33% in the control group（ P〈0. 05）; the 2-year and 3-year survival rate in the observation group was significantly higher than that in the control group,and the progression-free survival in the observation group was significantly longer than the control group（ P〈0. 05）; the incidence of liver and kidney toxicity,bone marrow suppression,gastrointestinal reactions in observation group were significantly higher than the control group（ P〈0. 05）. Conclusion： For the treatment of stage Ⅲ- Ⅳcolon adenocarcinoma with Jianpi Huashi Quyu Jiedu method can improve immune function and progression-free survival,improve survival and reduce side effects of chemotherapy.
出处
《中医学报》
CAS
2016年第12期1841-1845,共5页
Acta Chinese Medicine
基金
江苏省科技厅临床医学科技专项(BL2014099-Y0103)
关键词
结肠腺癌
肿瘤
健脾化湿祛瘀解毒法
中医药疗法
中西医结合
colon adenocarcinoma
tumor
Jianpi Huashi Quyu Jiedu method
TCM therapy
integrated traditional Chinese and western medicine
