摘要
目的:观察定喘汤加减辅助治疗老年急性发作期哮喘的临床疗效。方法:90例老年急性发作期哮喘患者按随机数字表法平均分为对照组和观察组。对照组45例予以常规疗法治疗,观察组45例在对照组治疗基础上予以定喘汤加减治疗。比较两组临床症状,肺功能变化,炎症介质,血清Ig E、NO及超氧化物歧化酶(superoxide dismutase,SOD)水平,临床疗效及并发症状况。结果:对照组有效率75.56%低于观察组有效率91.11%,差异具有统计学意义(P<0.05)。与对照组比较,观察组治疗后喘憋、咳嗽、肺部湿啰音及哮鸣音缓解时间缩短,治疗后第1秒用力呼气量(forced expiratory volume in 1 second,FEV1)、用力肺活量(forced vital capacity,FVC)、FEV1%和FEV1/FVC显著升高,差异均有具有统计学意义(P<0.05);治疗后血清白细胞介素-4(interleukin 4,IL-4)、IL-8、IL-9水平降低,IL-10水平升高,差异均有具有统计学意义(P<0.05);治疗后血清Ig E及NO水平降低,SOD水平升高,差异均有具有统计学意义(P<0.05)。结论:定喘汤加减辅助治疗老年急性发作期哮喘临床疗效显著,同时能改善肺功能及缓解炎症反应。
Objective： To investigate the clinical effect of Dingchuan decoction in the treatment of acute episode of asthma in the elderly. Methods： 90 cases of elderly patients with acute attack of asthma were selected and patients or family member signed an agreement,and randomly divided into 2 groups,45 cases in the control group were treated with symptomatic and supportive therapy,45 cases in the experiment group were treated on the base of the control group with Dingchuan decoction. Clinical symptoms,pulmonary function,inflammatory mediators and serum levels of Ig E,NO and SOD,and the clinical efficacy and complications were compared. Results： The effective rate of the control treatment group（ 75. 56%） was lower than the experiment group（ 91. 11%）,with significant difference（ P〈0. 05）,and compared with the control group,the time of asthma suppress,cough,lung wet rales and wheezes sound remission time in the experiment group were shorter,FEV1,FVC,FEV1% pre and FEV1 / FVC were higher,serum IL-4 and IL-8,IL-9 levels were lower,levels of IL-10 was higher,serum levels of Ig E and NO were lower and SOD level was higher（ P〈0. 05）. Conclusion： Dingchuan decoction auxiliary treatment of acute exacerbation of asthma in the elderly has significant effect,which can improve lung function and relieve inflammation reaction with high safety.
出处
《中医学报》
CAS
2016年第12期1870-1873,共4页
Acta Chinese Medicine
