摘要
目的:观察交泰丸加减对2型糖尿病伴失眠患者血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)及5-羟色胺水平(5-hydroxytryptamine,5-HT)的影响。方法:70例2型糖尿病伴失眠患者随机分成观察组和对照组,每组各35例。均予原控制血糖治疗方案,对照组在此基础上给予安定口服催眠治疗,观察组在对照组治疗基础上再给予交泰丸加减治疗,两组均治疗2周。检测血清空腹血糖、餐后2小时血糖(2 hours postprandial blood glucose,2h PG)、糖化血红蛋白(glycosylated hemoglobin,Hb A1C)水平,比较治疗前后血清5-HT、BDNF水平,匹茨堡睡眠质量指数量表评分及全身中医证候积分,临床疗效。结果:与治疗前比较,两组患者血清空腹血糖、2h PG水平降低(P<0.01),5-HT、BDNF水平升高(P<0.01),匹茨堡睡眠质量指数量表评分降低(P<0.01),心烦心悸、口渴喜饮证候积分降低(P<0.01);与对照组比较,观察组患者血清空腹血糖、2h PG水平较低(P<0.01),5-HT、BDNF水平较高(P<0.01),匹茨堡睡眠质量指数量表评分较低(P<0.01),心烦心悸、口渴喜饮、神疲腰酸以及夜尿频数证候积分较低(P<0.01),治疗有效率较高(P<0.05),随访失眠复发较低(P<0.05)。结论:交泰丸加减对2型糖尿病伴失眠患者具有降低血糖及改善睡眠的双重疗效,有效升高血清5-HT及BDNF水平,不良反应少。
Objective： To investigate the effect of Jiaotai Pill in the treatment of type 2 diabetes with insomnia in serum brain derived neurotrophic factor and 5-serotonin levels. Methods： 70 cases with type 2 diabetes with insomnia were selected and divided into 2groups,35 cases each. 2 groups received original control blood sugar treatment plan,the control group received diazepam tablet oral,the experiment group were treated on the base of the control group with Jiaotai Pill. 2 groups were treated for 2 weeks. Serum levels of FBG,2hP G,HbA 1C,serum 5-HT,BDNF levels,PSQI score and systemic TCM syndrome score,clinical efficacy and follow-up were compared. Result： Compared with before treatment,serum FBG,2hP G levels decreased（ P〈0. 01）,5-HT,BDNF levels increased（ P〈0. 01）,PSQI score decreased（ P〈0. 01）,Upset palpitations,thirst,lassitude and backache nocturia syndrome score decreased（ P〈0. 01）. Compared with the control group,serum FBG,2hP G levels were lower（ P〈0. 01）,5-HT,BDNF levels were higher（ P〈0. 01）,PSQI score was lower（ P〈0. 01）,upset palpitations,thirst with desire for drinks,lassitude and backache,nocturia symptom score were lower（ P〈0. 01）. the efficiency was higher（ P〈0. 05）,and the follow-up was lower（ P〈0. 05）. Conclusion： Jiaotai Pill in the treatment of type 2 diabetes with insomnia is effective,and it has the double effect of loweringblood sugar and improving sleep,and can increase the level of serum 5-HT and BDNF,and with lower adverse reaction.
出处
《中医学报》
CAS
2016年第12期1900-1903,共4页
Acta Chinese Medicine
关键词
2型糖尿病
失眠
交泰丸
5-羟色胺
脑源性神经营养因子
空腹血糖
餐后2小时血糖
糖化血红蛋白
中西医结合
type 2 diabetes mellitus
insomnia
Jiao Tai pill
5-serotonin
brain derived neurotrophic factor
fasting blood glucose
postprandial 2 hour blood glucose
glycosylated hemoglobin
integrated traditional Chinese and western medicine
