摘要
目的探讨胸腺五肽辅助化疗对肺癌患者免疫功能和生活质量的影响及意义。方法将78例肺癌患者随机分为治疗组和对照组,每组各39例。对照组采取单纯化疗,治疗组采用胸腺五肽联合化疗。观察和比较治疗前后2组患者的淋巴细胞比例变化、补体C3、C4和免疫球蛋白等免疫功能指标的变化,以及对其生活质量的影响。结果治疗组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+明显高于治疗前,CD8^+低于治疗前(P<0.05);与对照组比较差异有统计学意义(P<0.05)。治疗前后2组患者的补体和免疫球蛋白的变化没有统计学差异(P>0.05)。治疗后,2组患者的生活质量得到明显改善,治疗组的改善程度大于对照组(P<0.05)。2组患者的不良反应发生率无统计学差异(P>0.05)。结论胸腺五肽辅助化疗可促进肺癌患者免疫功能的恢复,提高患者生活质量,值得临床广泛应用。
Objective To explore the effect of thymopentin adjuvant chemotherapy on immune function and quality of life of patients with lung cancer. Methods 78 cases of lung cancer were randomly divided into the treatment group and the con- trol group, each with 39 cases. The control group was treated with chemotherapy only, while the treatment group was treated with chemotherapy combined with thymopentin. The changesof proportion of lymphocytes, C3, C4 and other immune function index such as immune globulin, and influence on the quality of life of the 2 groups before and after the treatment were observed and compared. Results The percentage of CD3＋ , CD4 ＋ , CD4＋/CD8 ＋ in the treatment group were significantly higher than before treat- ment（P 〈0.05）. The difference was statistically significant（ P 〈 0.05 ）. There was no significant difference in complement and immunoglobulin between the 2 groups before and after treatment（ P 〉 0.05 ）. After treatment ,the quality of life of the 2 groups improved significantly, the improvement of the treatment group was more than the control group（ P 〈 0.05 ）. There was no significant difference in the incidence of adverse reactions between the 2 groups （ P 〉 0.05 ）. Conclusion Hymopentin adjuvant chemotherapy for lung cancer can promote the recovery of the immune function, improve quality of life, and it is worthy of clinical application.
出处
《实用癌症杂志》
2016年第12期2017-2019,共3页
The Practical Journal of Cancer
关键词
胸腺五肽
肺癌
免疫功能
生活质量
Thymopentin
Lung cancer
Immune function
Quality of life
