摘要
目的 探讨替吉奥胶囊化疗同步三维适形放疗（3DCRT）治疗术后复发直肠癌（RCC）的临床疗效及安全性。方法 将60例复发直肠癌患者根据治疗方法的不同分为对照组和研究组,每组30例。2组都采用三维适形放疗治疗,研究组采用三维适形放疗同步替吉奥治疗。比较2组患者的临床疗效及不良反应发生率。结果 研究组有效率为73.33%,明显高于对照组的40.00%（χ2=6.79,P〈0.05）。研究组的中位无病进展时间（PFS）为11.2个月,显著高于对照组的8.7个月（P〈0.05）。研究组大体肿瘤体积（GTV）、计划靶区（PTV）、V20、小肠V20、心脏V40、放疗体积明显小于对照组（P〈0.05）;2组脊柱体积无明显差异（P〉0.05）。研究组和对照组Ⅲ、Ⅳ度中性粒细胞下降率分别为20.0%、3.3%,恶心呕吐率分别为30.0%、6.6%,腹泻率分别为23.3%、3.3%,研究组均显著高于对照组（P〈0.05）。结论 三维适形放疗同步替吉奥化疗治疗直肠癌术后复发的疗效确切,但其Ⅲ/Ⅳ级血液学毒性及胃肠道反应发生率高于单纯应用三维适形放疗。
Objective To explore the clinical effects and safety of Tegafur Gimeracil Oteracil Potassium capsule combined with three dimensional conformal radiation therapy for patients with recurrent colorectal cancer. Methods 60 cases of patients with recurrent colorectal cancer were divided into the control group and the research group according to different treatment methods, each with 30 cases. The patients were treated by three dimensional conformal radiation therapy, on the basis of the con- trol group, the research group were treated by Tegafur Gimeracil Oteracil Potassium capsule combined with three dimensional con-formal radiation therapy. Clinical effects and incidence of adverse reactions of the 2 groups were compared. Results The response rate of the research group （73.33%） was higher than the control group （40.00%） （ X^2 = 6.79, P 〈 0.05 ）. The PFS of the research group（ 11.2 months） was higher than the control group （ 8.7 months） （ P 〈 0.05 ）. The GTV, PTV, V20, intestine V20, heart V40, radiation volume of the research group was lower than the control group（ P 〈 0.05 ） ;There had no significant difference in the spinal volume between the 2 groups （ P 〉 0. 05 ）. Grade Ⅲ/Ⅳ neutrophilopenia rate of the research group （ 20.0% ） was higher than that of the control group（ 3.3% ） （ P 〈 0.05 ）. The rate of nausea and vomit of the research group（ 30.0% ） was higher than that of the control group（6.6% ） （P 〈0.05）. Diarrhea rate of the research group（23.3% ） was higher than that of the control group（3.3% ）（P 〈 0.05）. Conclusion Tegafur Gimeracil Oteracil Potassium capsule combined with three dimensional conformal radiation therapy for the patients with recurrent colorectal cancer is effective, but grade Ill/IV hematology toxicity and gastrointestinal reaction rate are higher than three dimensional conformal radiotherapy alone.
出处
《实用癌症杂志》
2016年第12期2033-2035,共3页
The Practical Journal of Cancer
基金
江西省卫计委课题科研项目(编号:20167201)
关键词
三维适形放疗
替吉奥
结直肠癌
复发
Radiotherapy
Tegafur gimeracil oteracil potassium capsule
Colorectal carcinoma
Recurrence
