不同麻醉方式对高龄患者术后认知功能障碍的影响被引量：1

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摘要目的:评价全麻和硬膜外阻滞对高龄患者术后认知功能障碍的影响。方法:选择高龄股骨近端骨折需外科治疗患者162例,随机分为全麻组和硬膜外阻滞组,每组81例,记录术前、术后24h、72h MMSE评分,研究术后POCD的发生情况。于术前、术后即刻、24和72h时分别采集肘静脉血样2ml,采用酶联免疫吸附(ELISA)法检测S-100β蛋白和β淀粉样蛋白(Aβ)浓度。结果:术后24h、72h全麻组与硬膜外阻滞组POCD的发生率分别为:34.6%(28/81)VS 24.7%(20/81),11.1%(9/81)VS 3.7%(3/81)(P均<0.05)。全麻组与硬膜外阻滞组两组患者术前血清S-100β蛋白和Aβ浓度差异无统计学意义(P>0.05),术后即刻均显著升高,差异有统计学意义(P<0.05);术后24h两种指标均有所降低,但差异仍有统计学意义(P<0.05);术后72h两种指标进一步降低,逐渐降至术前水平。结论:硬膜外阻滞较全麻可有效降低高龄患者术后认知功能障碍的发生率。

作者蒋凌霄石铸马江川

机构地区江苏省扬州市江都人民医院麻醉科

出处《医学理论与实践》 2016年第22期3090-3092,共3页 The Journal of Medical Theory and Practice

关键词全麻硬膜外阻滞高龄认知功能障碍

分类号 R614 [医药卫生—麻醉学]

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二级参考文献34

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