摘要
目的探讨肾上腺糖皮质激素联合麻杏石甘汤加减治疗慢性阻塞性肺疾病急性发作期(AECOPD)的临床疗效。方法选择100例AECOPD患者作为研究对象,随机分为观察组与对照组,所有患者均给予常规治疗,对照组加用肾上腺糖皮质激素治疗,观察组给予肾上腺糖皮质激素联合麻杏石甘汤加减治疗。治疗2周后比较2组临床疗效、临床症状评分及通气功能。结果治疗后,观察组临床疗效显著优于对照组(Z=2.123,P<0.05);观察组气短、喘息、痰量、咳嗽证候评分显著低于对照组(P均<0.05);观察组FEV_1、FVC、FEV_1/FVC均显著高于对照组(P均<0.05)。结论肾上腺糖皮质激素联合麻杏石甘汤加减治疗显著提高了AECOPD临床疗效,明显改善了患者临床症状和肺功能,且无严重不良反应的发生,值得临床重视。
Objective It is to investigate the curative effect of Maxingshigan decoction combined with glucocorticoid on a- cute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods One hundred cases of AECOPD patients were selected as study subjects, according to the random number table method they were divided into observation group （n = 50） and control group （n = 50）. All the patients were treated with conventional therapy, additionally the control group was treated with glucocorticoid, the observation group was treated with Maxingshigan decoction combined glucocortieoid. After 2 weeks of treatment, the clinical efficacy, clinical symptom score and ventilation function were compared between the two groups. Results After treatment, the clinical efficacy of the observation group was significantly better than that of the control group, the difference was statistically significant （Z = 2. 123,P 〈 0. 05 ） ; The syndrome scores of shortness of breath, wheez- ing, sputum and cough of the observation group were significantly lower than those of the control group （ P 〈 0.05 ） ; The FEV1 , FVC and FEV1/FVC of the observation group were significantly higher than the control group （ P 〈 0.05 ）. Conclusion Maxingshigan decoction combined with glueocorticoid can significantly improve the clinical efficacy of AECOPD, significantly improve the clinical symptoms and lung function in patients without serious adverse reactions occurred, it is worthy of atten- tion.
出处
《现代中西医结合杂志》
CAS
2017年第1期24-26,30,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
慢性阻塞性肺疾病急性发作期
麻杏石甘汤
肾上腺糖皮质激素
acute exacerbation of chronic obstructive pulmonary disease
Maxingshigan decoction
glucocorticoid
